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Mouse Models that Target Removal or Overexpression of the Selenocysteine tRNA[Ser]Sec Gene to Elucidate the Role of Selenoproteins in Health and Development

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Abstract

Several mouse models targeting the selenocysteine (Sec) tRNA[Ser]Sec gene for removal or overexpression have been generated and they include: (1) mice carrying a conditional knockout of the Sec tRNA gene; (2) transgenic mice encoding wild type or mutant Sec tRNA transgenes; and (3) conditional knockout/transgenic or standard knockout/transgenic mice carrying wild type or mutant Sec tRNA transgenes. These models have provided powerful tools for elucidating the roles of selenoproteins in development and health.

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Acknowledgements

This work was supported by the National Institutes of Health NCI Intramural Research Program and the Center for Cancer Research (to DLH) and by National Institutes of Health Grants (to VNG).

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Authors and Affiliations

  1. Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    Bradley A. Carlson, Min-Hyuk Yoo, Petra A. Tsuji, Ryuta Tobe, Salvador Naranjo-Suarez, Fang Chen & Dolph L. Hatfield

  2. Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    Petra A. Tsuji

  3. Laboratory Animal Science Program, Science Applications International Corporation, Frederick, MD, 21702, USA

    Lionel Feigenbaum

  4. Neural Development Group, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21701, USA

    Lino Tessarollo

  5. Department of Biological Sciences, Interdisciplinary Program for Bioinformatics, Seoul National University, Seoul, South Korea

    Byeong Jae Lee

  6. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02115, USA

    Vadim N. Gladyshev

Authors
  1. Bradley A. Carlson
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  2. Min-Hyuk Yoo
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  3. Petra A. Tsuji
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  4. Ryuta Tobe
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  5. Salvador Naranjo-Suarez
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  6. Fang Chen
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  7. Lionel Feigenbaum
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  8. Lino Tessarollo
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  9. Byeong Jae Lee
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  10. Vadim N. Gladyshev
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  11. Dolph L. Hatfield
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Corresponding author

Correspondence to Bradley A. Carlson .

Editor information

Editors and Affiliations

  1. National Cancer Institute, Basic Research Laboratory, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Dolph L. Hatfield

  2. University of Hawaii, Monoa, Dole Street 2444, Honolulu, 96822, Hawaii, USA

    Marla J. Berry

  3. , Division of Genetics, Department of Medi, Brigham and Women’s Hospital and Harvard, Avenue Louis Pasteur 77, Boston, 02115, USA

    Vadim N. Gladyshev

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© 2011 Springer Science+Business Media, LLC

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Carlson, B.A. et al. (2011). Mouse Models that Target Removal or Overexpression of the Selenocysteine tRNA[Ser]Sec Gene to Elucidate the Role of Selenoproteins in Health and Development. In: Hatfield, D., Berry, M., Gladyshev, V. (eds) Selenium. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1025-6_44

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