Abstract
The cell is the smallest autonomous unit of living tissue. A eukaryotic cell is characterized by many internal structures organized within membranes. These organelles include the nucleus, mitochondria, endoplasmic reticulum and the Golgi apparatus. There are, in addition, many internal vesicles that transport metabolic reagents and enzymes. The complex internal structures have differing protein and lipid densities and differing refractive indices that scatter light. The cellular structures are in constant motion, leading to highly dynamic light scattering (DLS).
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Selected Bibliography
Selected Bibliography
Boal, D.: Mechanics of the Cell.Cambridge (2002) (An excellent up-to-date viewpoint of the mechanical properties of cells)
Bray, D.: Cell Movements: From Molecules to Motility. Garland (2001) (A great reference text on all types of cell movements)
Evans, E.A., Skalak, R.: Mechanics and Thermodynamics of Biomembranes. CRC Press, Boca Raton (1980) (This is the classic original work on mechanics of membranes)
Reif, F.: Fundamentals of Statistical and Thermal Physics. McGraw-Hill, New York (1965) (A good source for the fluctuation-dissipation theorem)
Squires, T.M., Mason, T.G.: Fluid mechanics of microrheology. Annu. Rev. Fluid Mech. 42, 413–438 (2010) (A good recent review on the generalized Stokes Einstein relation)
References
Wax, A., Yang, C.H., Backman, V., Badizadegan, K., Boone, C.W., Dasari, R.R., Feld, M.S.: Cellular organization and substructure measured using angle-resolved low-coherence interferometry. Biophys. J. 82(4), 2256–2264 (2002)
Liu, Y., Li, X., Kim, Y.L., Backman, V.: Elastic backscattering spectroscopic microscopy. Opt. Lett. 30(18), 2445–2447 (2005)
Mourant, J.R., Freyer, J.P., Hielscher, A.H., Eick, A.A., Shen, D., Johnson, T.M.: Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics. Appl. Opt. 37(16), 3586–3593 (1998)
Wilson, J.D., Foster, T.H.: Mie theory interpretations of light scattering from intact cells. Opt. Lett. 30(18), 2442–2444 (2005)
Drezek, R., Dunn, A., Richards-Kortum, R.: Light scattering from cells: finite-difference time-domain simulations and goniometric measurements. Appl. Opt. 38(16), 3651–3661 (1999)
Tuchin, V.: Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis. SPIE, Bellingham (2000).
Ingber, D.E.: Tensegrity I. Cell structure and hierarchical systems biology. J. Cell Sci. 116(7), 1157–1173 (2003)
Peterson, J.R., Mitchison, T.J.: Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chem. Biol. 9(12), 1275–1285 (2002)
Jordan, M.A., Wilson, L.: Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr. Opin. Cell Biol. 10(1), 123–130 (1998)
Ellis, R.J.: Macromolecular crowding: an important but neglected aspect of the intracellular environment. Curr. Opin. Struct. Biol. 11(1), 114–119 (2001)
Purcell, E.M.: Life at low Reynolds-number. Am. J. Phys. 45(1), 3–11 (1977)
Ritchie, K., Shan, X.Y., Kondo, J., Iwasawa, K., Fujiwara, T., Kusumi, A.: Detection of non-Brownian diffusion in the cell membrane in single molecule tracking. Biophys. J. 88(3), 2266–2277 (2005)
Hoffman, B.D., Crocker, J.C.: Cell mechanics: dissecting the physical responses of cells to force. Annu. Rev. Biomed. Eng. 11, 259–288 (2009)
Massiera, G., Van Citters, K.M., Biancaniello, P.L., Crocker, J.C.: Mechanics of single cells: rheology, time depndence, and fluctuations. Biophys. J. 93(10), 3703–3713 (2007)
Squires, T.M., Mason, T.G.: Fluid mechanics of microrheology. Annu. Rev. Fluid Mech. 42, 413–438 (2010)
Reif, F.: Fundamentals of Statistical and Thermal Physics. McGraw-Hill, New York (1965).
Wilhelm, C.: Out-of-equilibrium microrheology inside living cells. Phys. Rev. Lett. 101(2), 028101 (2008)
Gallet, F., Arcizet, D., Bohec, P., Richert, A.: Power spectrum of out-of-equilibrium forces in living cells: amplitude and frequency dependence. Soft Matter 5(15), 2947–2953 (2009)
Lau, A.W.C., Hoffman, B.D., Davies, A., Crocker, J.C., Lubensky, T.C.: Microrheology, stress fluctuations, and active behavior of living cells. Phys. Rev. Lett. 91(19), 198101 (2003).
Mizuno, D., Tardin, C., Schmidt, C.F., MacKintosh, F.C.: Nonequilibrium mechanics of active cytoskeletal networks. Science 315(5810), 370–373 (2007)
MacKintosh, F.C., Levine, A.J.: Nonequilibrium mechanics and dynamics of motor-activated gels. Phys. Rev. Lett. 100(1), 018104 (2008).
Boal, D.: Mechanics of the Cell. Cambridge University Press, Cambridge, (2002).
Shkulipa, S.A., den Otter, W.K., Briels, W.J.: Simulations of the dynamics of thermal undulations in lipid bilayers in the tensionless state and under stress. J. Chem. Phys. 125(23), 234905 (2006)
Luby-Phelps, K.: Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area. In: International Review of Cytology – a Survey of Cell Biology, vol 192, pp. 189–221 (2000)
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Nolte, D.D. (2012). Cell Structure and Dynamics. In: Optical Interferometry for Biology and Medicine. Bioanalysis, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0890-1_8
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DOI: https://doi.org/10.1007/978-1-4614-0890-1_8
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