Abstract
Stress responses of pancreatic cancer cells are detected in case of chemotherapy. We have reported the expression of various stress proteins in pancreatic cancer cells with special reference to tumor aggressiveness. Here, we elucidated a previously unknown function of SMG-1, one of PI3 kinases, in the signal transduction of stress responses. Gemcitabine induces epithelial–mesenchymal transition (EMT), producing EMT-inducing factors. Regulation of stress responses might lead to the control of metastasis and the overcome of drug resistance in pancreatic cancer.
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Motoo, Y., Xia, QS., Nakaya, N., Shimasaki, T., Nakajima, H., Ishigaki, Y. (2012). Stress Responses of Pancreatic Cancer Cells and Their Significance in Invasion and Metastasis. In: Soh, KS., Kang, K., Harrison, D. (eds) The Primo Vascular System. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0601-3_30
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DOI: https://doi.org/10.1007/978-1-4614-0601-3_30
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