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Primo Microcell in a Primo Node as a Possible Origin of Adult Stem Cells

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The Primo Vascular System

Abstract

Adult stem cells have been intensively studied for their cell-therapeutic potential to renew damaged tissues or organs because their use eliminates the ethical, legal, and political concerns with using embryonic stem cells. On the other hand, a microcell contains a micronucleus that has one or a few chromosomes with a small amount of cytoplasm. Recently, microcells have become a possible origin of adult stem cells because of their ability to induce undifferentiated cells. In the early 1960s, after its first observation by Kim, the primo vascular system (PVS) was thought to be an anatomical basis for traditional acupuncture systems (termed kyungrak theory or meridians). Kim also claimed that about 1.0-μm-sized DNA-containing granules, named primo microcells or sanals, flowed through the PVS consisting of primo vessels and primo nodes to internal organs to proliferate and differentiate into specific cells in the organs in a manner similar to that of adult stem cells. In this study, we harvested primo microcells from Sprague Dawley rats about 250–300 g. The primo microcells were observed to grow into cell-like body entities. These interesting results suggest that Kim’s manual pictures from his article 1965 and Sanal theory may be true based on experimental studies similar to ours. Also, primo microcells in primo nodes might be one possible origin of adult stem cells. Understanding the primo microcell is thought to be one of the most fundamental studies for cell therapy.

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Author information

Authors and Affiliations

  1. Department of Meridian and Acupoint, College of Oriental Medicine, Wonkwang University, Jeollabuk, South Korea

    In-chul Sohn

  2. Research Center of Traditional Korean Medicine, Wonkwang University, Jeollabuk, South Korea

    In-chul Sohn

Authors
  1. Seong-hun Ahn
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  2. Sung-won Lee
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  3. Sung-Yeoun Hwang
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  4. Jae-hyo Kim
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  5. In-chul Sohn
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Corresponding author

Correspondence to In-chul Sohn .

Editor information

Editors and Affiliations

  1. , Advanced Institute of Convergence Techno, Seoul National University, Seoul, 443-270, Korea, Republic of (South Korea)

    Kwang-Sup Soh

  2. , Department of Chemical Engineering, University of Louisville, Louisville, 40292, Kentucky, USA

    Kyung A. Kang

  3. , Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom

    David K Harrison

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© 2012 Springer Science+Business Media, LLC

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Ahn, Sh., Lee, Sw., Hwang, SY., Kim, Jh., Sohn, Ic. (2012). Primo Microcell in a Primo Node as a Possible Origin of Adult Stem Cells. In: Soh, KS., Kang, K., Harrison, D. (eds) The Primo Vascular System. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0601-3_23

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