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Investigating the Role of Cross-Talk Between Chemical and Stromal Factors in Endothelial Cell Phenotype Determination

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Modeling Tumor Vasculature

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Abstract

Signal transduction is part of a complex communication system responsible for regulating fundamental cellular activities, including metabolism, protein synthesis, division, migration, and survival. The capacity of cells to perceive and precisely respond to their environment is critical to development, tissue repair, and normal tissue homeostasis. Vast amounts of disparate, postgenomic data facilitated by the development of high-throughput technologies are now available and computational modeling is needed to synthesize and understand these data within their systems biology context. In this chapter, we discuss computational approaches available to model signal transduction and present several types of Boolean network models of cell signaling during tumor angiogenesis. Using these models, we investigate the role of cross-talk between chemical and stromal factors in endothelial cell phenotype determination. Understanding the principal mechanisms underpinning the functions of signalling networks will enable identification of targets for pharmacological interventions in the treatment of cancer and other angiogenesis-dependent diseases.

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Authors and Affiliations

  1. Theoretical Division, Los Alamos National Laboratory, Theoretical Biology and Biophysics Group, T-082, Los Alamos, NM, 87545, USA

    Amy L. Bauer

  2. Epigenomics Project, Genopole, Evry and MPI-MIS, ISSB, Genopole Campus 1, Genavenir 6, 5 rue Henri Desbrueres, F-91030, EVRY cedex, France

    Thimo Rohlf

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  1. Amy L. Bauer
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  2. Thimo Rohlf
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Correspondence to Amy L. Bauer .

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  1. Dept. Mathematics, University of Michigan, 530 Church Street, Ann Arbor, Michigan, 48109, USA

    Trachette L. L. Jackson

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Bauer, A.L., Rohlf, T. (2012). Investigating the Role of Cross-Talk Between Chemical and Stromal Factors in Endothelial Cell Phenotype Determination. In: Jackson, T.L. (eds) Modeling Tumor Vasculature. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0052-3_4

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