Abstract
Although the genesis and constituents of lymphoid tissue germinal centers are not clearly defined, there is evidence that they are induced by antigen, and may play a role in T-B cell cooperation (1–3), generation of immunological memory (4), and differentiation of antibody-forming cells (5–6). Since we had previously demonstrated T antigen positive cells as constituents of germinal centers, we wished to test their induction in “oligosynthetic” lymph nodes with defined antigens. We chose three classes of antigen — thymus dependent antigens, thymus-independent antigens which induce antibodies limited to the IgM class, and a newly-described thymus-independent antigen, DNP32- Ficoll, which induces both IgM and IgG antibodies.
Supported by NIH grant AI-09072; ILW is a Faculty Research Awardee of the American Cancer Society
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References
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© 1976 Plenum Press, New York
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Weissman, I.L., Gutman, G.A., Friedberg, S.H., Jerabek, L. (1976). Lymphoid Tissue Architecture. III. Germinal Centers, T Cells, and Thymus-Dependent vs Thymus-Independent Antigens. In: Feldman, M., Globerson, A. (eds) Immune Reactivity of Lymphocytes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4355-4_35
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DOI: https://doi.org/10.1007/978-1-4613-4355-4_35
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