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Alphafetoprotein as a Marker for Early Events and Carcinoma Development During Chemical Hepatocarcinogenesis

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Application of Biological Markers to Carcinogen Testing

Part of the book series: Environmental Science Research ((ESRH,volume 29))

Abstract

Animal bioassays for carcinogens depend on evaluation of morphologic changes in affected organs following carcinogen exposure. In rats and mice this procedure is expensive, and evaluation of the morphologic changes that occur before obvious cancer develops are subject to disagreement among pathologists. In particular, the reversible morphologic changes that occur in the liver upon exposure to chemical hepatocarcinogens have been given different interpretations by different pathologists (1–5). Terms used vary from “preneoplastic,” implying a lesion that will eventually develop into a cancer, to “hyperplastic” or “benign proliferative lesion,” which implies that it does not develop into cancer.

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Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston, Texas, USA

    S. Sell, K. Osborn & J. Salman

  2. M.D. Anderson Hospital and Tumor Institute, Houston, Texas, USA

    F. Becker

  3. University of California at San Diego, San Diego, California, USA

    H. Leffert

  4. University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    B. Lombardi & H. Shinozuka

  5. Northwestern University Medical School, Chicago, Illinois, USA

    J. Reddy

  6. LaJolla Cancer Research Foundation, LaJolla, California, USA

    E. Ruoslahti

  7. Laboratoire d’Enzymologie du C.N.R.S., Gif. sur-Yvette, France

    J. Sala-Trepat

Authors
  1. S. Sell
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  2. F. Becker
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  3. H. Leffert
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  4. K. Osborn
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  5. J. Salman
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  6. B. Lombardi
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  7. H. Shinozuka
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  8. J. Reddy
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  9. E. Ruoslahti
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  10. J. Sala-Trepat
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Editor information

Editors and Affiliations

  1. United States Environmental Protection Agency, Washington, D.C., USA

    Harry A. Milman

  2. University of Texas Health Science Center, Houston, Texas, USA

    Stewart Sell

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© 1983 Plenum Press, New York

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Sell, S. et al. (1983). Alphafetoprotein as a Marker for Early Events and Carcinoma Development During Chemical Hepatocarcinogenesis. In: Milman, H.A., Sell, S. (eds) Application of Biological Markers to Carcinogen Testing. Environmental Science Research, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3790-4_22

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  • DOI: https://doi.org/10.1007/978-1-4613-3790-4_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3792-8

  • Online ISBN: 978-1-4613-3790-4

  • eBook Packages: Springer Book Archive

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