Skip to main content
SpringerLink
Log in

The Role of IgE and Its Receptor in Mediating Secretion

  • Chapter
Protein Conformation as an Immunological Signal

Abstract

In this review I shall describe our current view about antigen-induced, antibody-mediated stimulation of mast cells and basophils, and shall also give some comparative data on similar effector systems. I will focus particularly on those molecular events which occur early. These are of special interest because interference with these early steps may offer an especially fruitful opportunity for therapeutic intervention with a minimum of harmful side reactions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. H. Metzger, The effect of antigen on antibodies: Recent studies, Contemp. Topics Molec. Immuno. 7: 191 (1978).

    Google Scholar 

  2. C. Fewtrell, M. Geier, A. Goetze, D. Holowka, D. E. Isenman, J. F. Jones, H. Metzger, M. Novia, D. Siekmann, E. Silverton and K. Stein, Mediation of effector functions by antibodies: Report of a workshop, Molecular Immunol. 16: 741 (1979).

    Article  CAS  Google Scholar 

  3. L. M. Amzel and R. J. Poljak, Three-dimensional structure of immunoglobulins, Ann. Rev. Biochem. 48: 961 (1979).

    Article  PubMed  CAS  Google Scholar 

  4. R. R. Porter and K. B. Reid, The biochemistry of complement, Nature 175: 699 (1978).

    Article  Google Scholar 

  5. K. J. Dorrington, The structural basis for the functional versatility of immunoglobulin G, Can. J. Biochem. 56: 1087 (1978).

    CAS  Google Scholar 

  6. A. Kulczycki, Jr., and H. Metzger, The interaction of IgE with rat basophilic leukemia cells. II. Quantitative aspects of the binding reaction, J. Exp. Med. 140: 1676 (1974).

    Article  PubMed  Google Scholar 

  7. G. Rossi, S. A. Newman and H. Metzger, Assay and partial characterization of the solubilized cell surface receptor for immunoglobulin E, J. Biol. Chem. 252: 704 (1977).

    PubMed  CAS  Google Scholar 

  8. D. M. Segal and E. Hurwitz, Binding of affinity cross-linked oligomers of IgG to cells bearing Fc receptors, J. Immunol. 118: 1338 (1977).

    PubMed  CAS  Google Scholar 

  9. J. Schlessinger, W. W. Webb, E. L. Elson and H. Metzger, Lateral motion and valence of Fc receptors on rat peritoneal mast cells, Nature 264: 550 (1976).

    Article  PubMed  CAS  Google Scholar 

  10. G. R. Mendoza and H. Metzger, Distribution and valency of receptor for IgE on rodent mast cells and related tumor cells, Nature 264: 548 (1976).

    Article  PubMed  CAS  Google Scholar 

  11. D. Holowka, H. Hartmann, J. Kanellopoulos and H. Metzger, Association of the receptor for immunoglobulin E with an endogenous polypeptide on rat basophilic leukemia cells, J. Receptors Res. 1: 41 (1980).

    CAS  Google Scholar 

  12. S. A. Newman, G. Rossi and H. Metzger, The molecular weight and valency of the cell receptor for IgE. Proc. Natl. Acad. Sci. 74: 869 (1977).

    Article  PubMed  CAS  Google Scholar 

  13. D. H. Conrad and A. Froese, Characterization of the target cell receptor for IgE II Polyacrylamide gel analysis of the sur face IgE receptor from normal rat mast cells and from rat basophilic leukemia cells, J. Immunol. 116: 319 (1976).

    PubMed  CAS  Google Scholar 

  14. A. Kulczycki, Jr., T. A. McNearney and C. W. Parker, The rat basophilic leukemia cell receptor for IgE. Characterization as a glycoprotein, J. Immunol. 117: 661 (1976).

    PubMed  CAS  Google Scholar 

  15. J. M. Kanellopoulos, T. Y. Liu, G. Poy and H. Metzger, Composition and subunit structure of the cell receptor for immunoglobulin E, J. Biol. Chem. 255: 9060 (1980).

    PubMed  CAS  Google Scholar 

  16. A. Goetze, J. Kanellopoulos, D. Rice and H. Metzger, Enzymatic cleavage products of the a-subunit of the receptor for IgE, Biochemistry (in press).

    Google Scholar 

  17. D. Holowka, C. Gitler, T. Bercovici and H. Metzger, Reaction of 5-iodonaphthyl-1-nitrene with the receptor for IgE on normal and tumor mast cells, Nature 289: 806 (1981).

    Article  PubMed  CAS  Google Scholar 

  18. D. Holowka and H. Metzger, Further characterization of the ß-component of the receptor for immunoglobulin E, Molec. Immunol. (in press).

    Google Scholar 

  19. I. S. Mellman and J. C. Unkeless, Purification of a functional mouse Fc receptor through the use of a monoclonal antibody, J. Exp. Med. 152: 1048 (1980).

    Article  PubMed  CAS  Google Scholar 

  20. B. Uvnas, Histamine storage and release, Fed. Proc. 33: 2172 (1974).

    PubMed  CAS  Google Scholar 

  21. D. M. Segal, J. D. Taurog and H. Metzger, Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation, Proc. Natl. Acad. Sci. USA 74: 2993 (1977).

    Article  PubMed  CAS  Google Scholar 

  22. C. Fewtrell and H. Metzger, Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells, J. Immunol. 125: 701 (1980).

    PubMed  CAS  Google Scholar 

  23. A. Kagey-Sobotka, M. Dembo, B. Goldstein, H. Metzger and L. M. Lichtenstein, Qualitative characteristics of histamine release from human basophils by covalently crosslinked IgE, J. Immunol. (in press).

    Google Scholar 

  24. T. Ishizaka and K. Ishizaka, Triggering of histamine release from rat mast cells by divalent antibodies against IgEreceptors, J. Immuno. 120: 800 (1978).

    CAS  Google Scholar 

  25. C. Isersky, J. D. Taurog, G. Poy and H. Metzger, Triggering of culture mastocytoma cells by antibodies to the receptor for IgE, J. Immunol. 121: 549 (1978).

    PubMed  CAS  Google Scholar 

  26. P. H. Plotz, R. P. Kimberly, R. L. Guyer and D. M. Segal, Stable model immune complexes produced by bivalent affinity labeling haptens: Invivo survival, Mol. Immunol. 16: 721 (1979).

    Article  PubMed  CAS  Google Scholar 

  27. J. Tschopp, T. Schulthess, J. Engel and J. C. Jaton, Antigenindependent activation of the 1st component of complement CI by chemically crosslinked rabbit IgG oligomers FEBS Letters 112: 152 (1980).

    Article  PubMed  CAS  Google Scholar 

  28. T. J. Sullivan, K. L. Parker, A. Kulczycki, Jr., and C. W. Parker, Modulation of cyclic AMP in purified rat mast cells. III. Studies on the effects of concanavalin A and anti IgE on cyclic concentrations during histamine release, J. Immunol. 117: 713 (1976).

    PubMed  CAS  Google Scholar 

  29. R. A. Lewis, S. T. Holgate, L. J. Roberts II, J. E. Maquire, J. A. Oates and K. F. Austen, Effects of indomethacin on cyclic nucleo-tide levels and histamine release from rat serosal mast cells, J. Immunol. 123: 1663 (1979).

    PubMed  CAS  Google Scholar 

  30. F. Hirata, J. Axelrod and F. T. Crews, Concanavalin A stimulates phospholipid methylation and phosphatidyl serine decarboxylation in rat mast cells, Proc. Natl. Acad. Sci. 76: 4813 (1979).

    Article  PubMed  CAS  Google Scholar 

  31. T. Ishizaka, F. Hirata, K. Ishizaka and J. Axelrod, Stimulation of phospholipid methylation, Ca2 + influx and histamine release by bridging of IgE receptors on rat mast cells, Proc. Natl. Acad. Sci. 76: 4813 (1980).

    Google Scholar 

  32. S. Cockcroft and B. D. Gomperts, Evidence for a role of phosphatidylipsitol turnover in stimulus-secretion coupling: studies with rat peritoneal mast cells, Biochem. J. 178: 681 (1979).

    PubMed  CAS  Google Scholar 

  33. D. A. Kennerly, T. J. Sullivan and C. W. Parker, Activation of phospholipid metabolism during mediator release from stimulated rat mast cells, J. Immunol. 122: 152 (1979).

    PubMed  CAS  Google Scholar 

  34. J. C. Foreman, M. B. Hallet and J. L. Mongar, The relationship between histamine secretion and 45Ca uptake by mast cells, J. Physiol. 271: 193 (1977).

    PubMed  CAS  Google Scholar 

  35. T. Ishizaka, J. C. Foreman, A. R. Sterk and K. Ishizaka, Induction of calcium flux across the rat mast cell membrane by bridging IgE receptors, Proc. Natl. Acad. Sci. USA 76: 5858 (1979).

    Article  PubMed  CAS  Google Scholar 

  36. C. Fewtrell and H. Metzger, Stimulus-secretion coupling in rat basophilic leukaemia cells, in “Biochem. of Acute Allergic Reactions,” K. F. Austen and E. Becker, eds., (in press).

    Google Scholar 

  37. T. Suzuki, R. Sadasivan, T. Taki and G. M. Helmkamp, Jr., Studies of Fc receptors of human β lymphocytes: Phospholipase A2 activity of Fc γ receptors, Biochemistry 19: 6037 (1980).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute of Arthritis, Metabolism and Digestive Diseases, Arthritis and Rheumatism Branch, Section on Chemical Immunology, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Henry Metzger

Authors
  1. Henry Metzger
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Genoa, Genoa, Italy

    Franco Celada

  2. University of California, Los Angeles, California, USA

    Verne N. Schumaker  & Eli E. Sercarz  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Plenum Press, New York

About this chapter

Cite this chapter

Metzger, H. (1983). The Role of IgE and Its Receptor in Mediating Secretion. In: Celada, F., Schumaker, V.N., Sercarz, E.E. (eds) Protein Conformation as an Immunological Signal. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3778-2_51

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3778-2_51

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3780-5

  • Online ISBN: 978-1-4613-3778-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation