Abstract
It was realized quite early1, that contrary to the situation in the B cell universe in which reduced and native proteins are completely non-cross-reactive, denatured protein antigens cross-react very well with native proteins in delayed-hypersensitivity responses. This has been a consistent finding subsequently in many T cell systems using a variety of antigens. It appeared that T cells were restricted therefore to “seeing” continuous or sequential antigenic determinants and in most systems, it could be concluded that reduction and fragmentation of antigen were prerequisites to activation.
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References
P.G. Gell and B. Benacerraf, Delayed hypersensitivity to simple protein antigens, Adv.Immunol. 1:319 (1961).
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© 1983 Plenum Press, New York
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Celada, F., Schumaker, V.N., Sercarz, E.E. (1983). General Introduction. In: Celada, F., Schumaker, V.N., Sercarz, E.E. (eds) Protein Conformation as an Immunological Signal. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3778-2_30
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DOI: https://doi.org/10.1007/978-1-4613-3778-2_30
Publisher Name: Springer, Boston, MA
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