Abstract
In order to best assess the genetic risks to humans of environmental factors, investigations of their effects in mammalian systems will be necessary. For the forseeable future most such studies will be conducted on laboratory animals, and in particular, because of the large body of existing information on its biology and genetics, the laboratory mouse.
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E. Vogel and F. H. Sobels, The function of Drosophila in genetic toxicology testing, in: “Chemical Mutagens: Principles and Methods for their Detection,” A. Hollaender, ed., Vol. 4, pp. 93–142, Plenum Press, New York (1976).
T. C. Carter and Mary F. Lyon, An attempt to estimate the induction by x-rays of recessive lethal and visible mutations in mice, Genet. Res., 2:296–305 (1961).
Mary F. Lyon, Rita J. S. Phillips, and A. G. Searle, The overall rates of dominant and recessive lethal and visible mutation induced by spermatogonial x-irradiation of mice, Genet. Res., 5:448–467 (1964).
K. G. Lüning, William Sheridan, and H. Frölén, Genetic effects of supralethal x-ray treatment of male mice, Mutat. Res., 2: 60–66 (1965).
William Sheridan, The effects of acute single or fractionated x-ray treatment on mouse spermatogonia, Mutat. Res., 5:163–172 (1968).
William Sheridan, The radiosensitivity of offspring of an irradiated mouse population, I. Effects on the redproductive capacity of irradiated female offspring, Mutat. Res., 4:675–781 (1967).
William Sheridan, The effects of the time interval in fractionated x-ray treatment of mouse spermatogonia, Mutat. Res., 13: 163–169 (1971).
H. W. Michelmann and W. Sheridan, Effects of transmitted translocations in mice, Abstracts of 9th annual meeting of Environmental Mutagen Society, p. 47 (1978).
William Sheridan, The induction by x-irradiation of dominant lethal mutations in spermatogonia of mice, Mutat. Res., 2:67–74 (1965).
M. A. Hamilton and J. K. Haseman, Statistical tests for recessive lethal-carriers, Mutat. Res., 64:269–278 (1979).
K. G. Lüning, Test of recessive lethals in the mouse, Mutat. Res., 27:357–366 (1975).
K. G. Lüning and A. G. Searle, Estimates of the genetic risks from ionizing irradiation, Mutat. Res., 12:291–304 (1971).
Nils Ryman, The frequency of recessive lethal heterozygotes among individuals obtained from inbred strains, A random-number simulation study, Mutat. Res., 42:363–372 (1977).
K. G. Lüning, Testing for recessive lethals in mice, Mutat. Res., 11:125–132 (1971).
J. B. S. Haldane, The detection of autosomal lethals in mice by mutagenic agents, J. Genet., 54:327–342 (1956).
E. R. Soares and W. Sheridan, Triethylenemelamine induced dominant lethals in mice — comparisons of oral versus intraperitoneal injection, Mutat. Res., 43:247–254 (1977).
K. Bürki and William Sheridan, Expression of TEM-induced damage to postmeiotic stages of spermatogenesis of the mouse during early embryogenesis, I. Investigations with in vitro embryo culture, Mutat. Res., 49:259–268 (1978).
K. Bürki and William Sheridan, Expression of TEM-induced damage to postmeiotic stages of spermatogenesis of the mouse during early embryogenesis, II. Cytological investigations, Mutat Res., 52:107–115 (1978).
E. R. Soares, William Sheridan, J. K. Haseman, and M. Segall, Increased frequencies of aberrant sperm as indicators of mutagenic damage in mice, Mutat. Res., 64:27–35 (1979).
F. M. Johnson and Susan Lewis, The detection of ENU-induced mutations in mice by electrophoresis and the problem of evaluating the mutation rate increase (these proceedings).
E. R. Soares, TEM-induced gene mutations at enzyme loci in the mouse, Environ. Mutagen, 1:19–25 (1979).
B. M. Cattanach, Induction of paternal sex-chromosome losses and deletions and of autosomal gene mutations by the treatment of mouse postmeiotic germ cells with triethylenemelamine, Mutat Res., 4:73–82 (1967).
UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) report to the General Assembly: Sources and Effects of Ionizing Radiation, United Nations, New York (1977).
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© 1983 Plenum Press, New York
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Sheridan, W. (1983). The Detection of Induced Recessive Lethal Mutations in Mice. In: de Serres, F.J., Sheridan, W. (eds) Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. Environmental Science Research, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3739-3_9
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DOI: https://doi.org/10.1007/978-1-4613-3739-3_9
Publisher Name: Springer, Boston, MA
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