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Factors That Influence Photocarcinogenesis

  • Chapter
Photoimmunology

Abstract

Laboratory animals have been shown to be susceptible to carcinogenesis by UV radiation. For example, the inbred strain of hairless (but immunologically competent) HRA/Skh mice normally develop very few spontaneous tumors; among mice that live for 2 yr, only about 6% have skin tumors, in a distribution of about 4 papillomas to 1 sarcoma to 1 carcinoma. However, when these animals are exposed to UV radiation under certain circumstances, all exposed animals can develop multiple, aggressive tumors in less than 1 yr. The proportion of affected mice, the multiplicity of tumors, the tumor types, and growth rates are all strongly influenced by circumstances of exposure and related events. This chapter considers some of those circumstances.

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Author information

Authors and Affiliations

  1. The Center for Photobiology, The Skin and Cancer Hospital, Temple University Health Sciences Center, Philadelphia, Pennsylvania, 19140, USA

    P. D. Forbes & R. E. Davies

Authors
  1. P. D. Forbes
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  2. R. E. Davies
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Editor information

Editors and Affiliations

  1. Massachusetts General Hospital, Boston, Massachusetts, USA

    John A. Parrish

  2. Frederick Cancer Research Facility, Frederick, Maryland, USA

    Margaret L. Kripke  & Warwick L. Morison  & 

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© 1983 Plenum Publishing Corporation

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Forbes, P.D., Davies, R.E. (1983). Factors That Influence Photocarcinogenesis. In: Parrish, J.A., Kripke, M.L., Morison, W.L. (eds) Photoimmunology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3670-9_7

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  • DOI: https://doi.org/10.1007/978-1-4613-3670-9_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3672-3

  • Online ISBN: 978-1-4613-3670-9

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