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Regulation of the Synthesis of 1,25-Dihydroxyvitamin D3 and 24,25- Dihydroxyvitamin D3 in Kidney Cell Culture

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Vitamin D

Abstract

The major circulating form of vitamin D, 25-hydroxyvitamin D3, is synthesized in the liver and serves as a pool of precursor for the dihydroxylated metabolites, l,25(OH)2D3 and 24,25(OH)2D3. l,25(OH)2D3 undoubtedly mediates the primary biological actions classically attributed to vitamin D in the intestine and bone. Although there has accumulated some evidence for a biological role for 24,25(OH)2D3 (1–4), the precise nature of this has not yet been elucidated. The kidney is generally considered to be the major site of synthesis of the dihydroxylated metabolites of vitamin D, although both can also be produced by extrarenal tissues such as the placenta (5,6) or by cells derived from extrarenal tissues such as bone (7,8).

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Authors
  1. Helen L. Henry
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Editors and Affiliations

  1. Department of Medicine, Mayo Clinic and Foundation, 200 First Street, S.W., Rochester, MN, 55905, USA

    Rajiv Kumar

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© 1984 Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster

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Henry, H.L. (1984). Regulation of the Synthesis of 1,25-Dihydroxyvitamin D3 and 24,25- Dihydroxyvitamin D3 in Kidney Cell Culture. In: Kumar, R. (eds) Vitamin D. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2839-1_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2839-1_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9793-2

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