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Induction of Calcium-Binding Protein in Embryonic Chick Duodenum In Vitro: Direct Assessment of Biopotency of Vitamin D-Steroids

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Vitamin D

Abstract

Among several physiologic activities, vitamin D controls the efficiency of intestinal calcium absorption as part of a complex mechanism for maintenance of calcium homeostasis (1). The single most-potent, naturally-occurring vitamin D metabolite (generally considered to be the biologically active form) is 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3). At the molecular level, l,25(OH)2D3 acts similarly to other hormonal steroids (2), in this case with de novo induction of a single new mRNA species coding for a calcium-binding protein (CaBP) in the intestine of vitamin D-deficient rachitic chicks (3,4). CaBP involvement in intestinal calcium absorption in intact chickens is supported by extensive correlative evidence (5).

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Authors
  1. Robert A. Corradino
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Editors and Affiliations

  1. Department of Medicine, Mayo Clinic and Foundation, 200 First Street, S.W., Rochester, MN, 55905, USA

    Rajiv Kumar

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© 1984 Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster

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Corradino, R.A. (1984). Induction of Calcium-Binding Protein in Embryonic Chick Duodenum In Vitro: Direct Assessment of Biopotency of Vitamin D-Steroids. In: Kumar, R. (eds) Vitamin D. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2839-1_12

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  • DOI: https://doi.org/10.1007/978-1-4613-2839-1_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9793-2

  • Online ISBN: 978-1-4613-2839-1

  • eBook Packages: Springer Book Archive

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