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A Pharmacodynamic Model for Thiazinamium in Asthmatic Patients

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Pharmacokinetics

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Abstract

Thiazinamium is a quaternary ammonium phenothiazine and clinically useful bronchodilator. Its mechanism of action is thought to be mediated by a combination of antimuscarinic and antihistaminic properties and its efficacy in the treatment of bronchoconstriction appears to be superior to epinephrine and aminophylline (1). Although it has been in clinical use for over 25 years, little is known about its pharmacokinetics and pharmacodynamics in humans (2,3). A prominent side effect of thiazinamium use is an increase in heart rate presumed to be due to vagal blockade. We have investigated the relationship between plasma thiazinamium concentration and the change in airways obstruction and heart rate to help provide rational dosing guidelines for the treatment of bronchoconstriction.

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References

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Author information

Authors and Affiliations

  1. Department of Pharmacology and Clinical Pharmacology, Auckland Medical School, Auckland, New Zealand

    N. H. G. Holford

  2. Department of Medicine, University of California, Los Angeles, California, USA

    P. Clements

  3. Department of Pharmacy, Queens University, Belfast, Northern Ireland

    P. Collier

  4. Departments of Medicine, Groningen, The Netherlands

    N. G. M. Orie & L. Eudia van Bork

  5. Pharmacy Rijkuniversiteit, Groningen, The Netherlands

    J. H. G. Jonkman

Authors
  1. N. H. G. Holford
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  2. P. Clements
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  3. P. Collier
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  4. N. G. M. Orie
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  5. L. Eudia van Bork
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  6. J. H. G. Jonkman
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Editor information

Editors and Affiliations

  1. School of Pharmacy, University of California, San Francisco, California, USA

    Leslie Z. Benet  & Bobbe L. Ferraiolo  & 

  2. School of Pharmacy, State University of New York, Buffalo, New York, USA

    Gerhard Levy

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© 1984 Plenum Press, New York

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Holford, N.H.G., Clements, P., Collier, P., Orie, N.G.M., van Bork, L.E., Jonkman, J.H.G. (1984). A Pharmacodynamic Model for Thiazinamium in Asthmatic Patients. In: Benet, L.Z., Levy, G., Ferraiolo, B.L. (eds) Pharmacokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2799-8_56

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  • DOI: https://doi.org/10.1007/978-1-4613-2799-8_56

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9725-3

  • Online ISBN: 978-1-4613-2799-8

  • eBook Packages: Springer Book Archive

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