Abstract
Riegelman and Collier have recently reviewed (1) the application of first moment analysis, also termed the mean residence time (MRT) method, to the evaluation ofin vivo absorption time using plasma concentration data following single dose administration. The object of the present report is to apply the MRT method, as well as conventional pharmacokinetic techniques, and to evaluate data derived from comparative bioavailability trials of controlled release formulations versus conventional products. The analyses were performed on data from single dose as well as from multiple dose studies conducted in our laboratories.
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Reference
S. Riegelman and P. Collier, The application of statistical moment theory to the evaluation ofin vivodissolution time, and absorption time, J. Pharmacokin. Biopharm. 8: 509 – 533 (1980).
J.C.K. Loo, N. Jordan, C. Charette, R. Brien and I.J. McGilveray, Pharmacokinetic evaluation of a conventional and controlled release product of betamethasone, Biopharm. Drug Dispos. 5: 97 – 100 (1984).
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© 1984 Plenum Press, New York
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Loo, J.C.K., Charette, C., Jordan, N., McGilveray, I.J. (1984). Application of Statistical Moment Analysis to the Evaluation of Controlled Release Formulations. In: Benet, L.Z., Levy, G., Ferraiolo, B.L. (eds) Pharmacokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2799-8_30
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DOI: https://doi.org/10.1007/978-1-4613-2799-8_30
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9725-3
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