Abstract
Although chemotherapy is one of the primary modalities in the treatment of neoplastic disease, it is severely limited in usefulness due to relative nonspecificity with a resultant high systemic toxicity. To a great extent, tumor cells are only marginally more susceptible to most anti-tumor agents compared to normal rapidly dividing host cells. As a result, for any oncolytic agents, there is a very narrow therapeutic index. This problem could be alleviated by the selective targeting of the desired drug to the tumor. In this fashion a therapeutically high local tumor concentration of the drug could be achieved with the administration of a significantly lower total systemic dose. In addition, systemic side effects would be virtually eliminated.
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© 1984 Springer-Verlag US
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Morris, R.M., Poore, G.A., Howard, D.P., Serfranka, J.A., Senyei, A.E., Widder, K.J. (1984). Magnetic Microspheres in Drug Delivery. In: Anderson, J.M., Kim, S.W. (eds) Recent Advances in Drug Delivery Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2745-5_15
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DOI: https://doi.org/10.1007/978-1-4613-2745-5_15
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