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Immunocytochemical Markers in Breast Cancer

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Immunocytochemistry in Tumor Diagnosis

Part of the book series: Developments in Oncology ((DION,volume 34))

Abstract

Tumor associated antigens (TAA) are presently used widely as markers of neoplasia and as a help in the evaluation and prognosis of the disease; such is the case with carcinoembryonic antigens (2,3) and alpha fetoprotein (3,5). However, these particular TAA are not specific markers for a given type of cancer, because they can be detected in different kinds of tumors, such as lung carcinoma (1), mucinous ovarian carcinoma (7), as well as in breast carcinomas (9). At the present time, however, no TAA can be considered breast specific. What is needed is a set of immunocytochemical markers that allows us: a) to determine the breast epithelial nature of neoplastic tissues, b) to define the neoplastic characteristics, c) be of prognostic significance and, (d) have therapeutic application. In this review, I will concentrate my attention on the three first topics. The use of monoclonal antibodies as a therapeutic tool has been reviewed by other authors (9–11).

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  1. Jose Russo M.D.
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    Jose Russo

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Russo, J. (1985). Immunocytochemical Markers in Breast Cancer. In: Russo, J. (eds) Immunocytochemistry in Tumor Diagnosis. Developments in Oncology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2615-1_13

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