Abstract
The introduction of new cytostatic drugs and their clinical use in combination of radiotherapy and of bone marrow transplantation procedures have changed the clinical picture of leukemia. The prognosis for children with acute lymphoblastic leukemia (ALL) has already improved considerably since 1960. Nowadays, a first complete remission is achieved in 85 to 95% of these children with two to four drug induction schemes [1, 2, 3].
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Pinkel D, Simone J, Hustu HO, Aur RJA: Nine years experience with total therapy of childhood lymphocytic leukemia. Pediatrics, 1972; 50: 246–5l.
Aur RJA, Simone JV, Venzosa MS, Hustu HO, Basker LF, Pinkel DP, Revira G, Hahl GV, Wood A, Stanger A, Mason C: Childhood acute lymphocytic leukemia. Cancer, 1978; 42: 2123–34.
Chessels JM: Acute lymphoblastic leukemia. Semin Hematol, 1982; 19: 155–71.
Haas RJ, Janka G, Netzel B, Helmig M: Munich ALL 77–01 study of treatment of acute lymphoblastic leukemia in childhood. Klin Pediatr, 1981; 193: 137–44.
Simone JV, Verzosa MS, Rudy JA: Initial features and prognosis in 363 children with acute lymphocytic leukemia. Cancer, 1975; 36: 2009–2108.
Simone JV: Leukemia remission and survival. Lancet, 1981; 2: 531.
Vogler LB, Crist WM, Sariff AM, Pullen DJ, Bartolucci AA, Falletta JM, Dowell B, Humphrey GB, Blackstock R, Eys vG, Metzgar G, Cooper MD: An analysis of clinical and laboratory features of acute lymphocytic leukemias with emphasis on 35 children with pre B leukemia. Blood, 1981; 58: 135–40.
Vries EGE de: Clinical and laboratory aspects of leukemia. Academic Thesis, University of Groningen, 1982; 26–40. Ed van Denderen, Groningen.
Evans AE, Gilbert ES, Zandstra R: The increasing incidence of central nervous system leukemia in children. Cancer, 1970; 26: 404–9.
Green DM, Freeman AI, Sather HS, Sallan SE, Nesbit ME, Cassady JR, Sinks LF, Hammond D, Frei E: Comparison of three methods of central nervous system prophylaxis in childhood acute lymphoblastic leukemia. Lancet, 1980; 1 1398–1402.
Nesbit ME, Sather HN, Robinson LL, Ortega J, Littman PS, d’Angio GJ, Hammond GD: Pre-symptomatic central nervous system therapy in previously untreated childhood acute lymphoblastic leukemia comparison of 1800 and 2400 Rad. A report for Children’s Cancer Study Group. Lancet, 1981; i: 461–65.
Lister TA, Rohatiner AZ: Treatment of acute myelogenous leukemia in adults. Semin Hematol, 1982; 19: 17292.
Mayer RJ, Weinstein HJ, Rosenthal DS, Coral FS, Nathan DG, Frei E: VAPA; A treatment program for acute myelocytic leukemia. Haematol Blood Tansf, 1981; 26: 45–52.
Gale RP, Kay HE, Rimm AA, Bortin MM: Bone marrow transplantation for acute leukaemia in first remission. Lancet, 1982; ii: 1006–9.
Barrett J, de Koning J: Supportive care in bone marrow transplantation. In: Supportive Therapy in Haematology, Das PC, Smit Sibinga CTh, Halie MR (eds). Martinus Nijhoff, Boston, 1985.
Thomas ED: The role of marrow transplantation in the eradication of malignant disease. Cancer, 1982; 49: 1963–69.
Spiers ASD, Booth AE, Frith JL: Subcutaneous cerebrospinal reservoirs in patients with acute leukemia. Scand Haematol, 1978; 20: 289–96.
Klose HJ, Kelson S, Schwarzbach K, Janka G, Netzel B, Haas R, Betke K: Initial treatment of acute childhood leukemia with extreme leucocytosis by blood exchange transfusion: rheological aspects. Klin Paediatr, 1981; 193: 172–76.
Drapkin RL, Gee TS, Dowling MD, Arlin Z, McKenzie S, Kempin S, Clarkson B: Prophylactic heparintherapy in acute promyelocytic leukemia. Cancer, 1978; 41: 2484–90.
Bauer TW, Haskins GE, Armitage JD: Splenic rupture in patients with haematological malignancies. Cancer, 1981; 48: 2729–33.
Cervantes F: Tumour lysis syndrom with hypocalciaemia in accelerated chronic granulocytic leukaemia. Acta Haemat, 1982; 68: 157–59.
Young RC, Ozolo RF, Myers CE: The anthracycline antineoplastic drugs. N Engl J Med, 1981; 305: 139–53.
Billingham ME, Mason JW, Bristow MR, Daniels JR: Anthracycline cardiomyopathy monitored by morphological changes. Cancer Treat Rep, 1978; 62: 865–72.
Steinherz PG, Miller LP, Ghavimi F, Allen JC, Miller DR: Dural sinus thrombosis in children with acute lymphoblastic leukemia. JAMA, 1981; 246: 2837–39.
Simone J: Acute lymphoblastic leukemia in childhood. Semin Haematol, 1974; 11: 25–39.
Komp DM, Fernandes CH, Falletta JM, Ragab AH, Humphrey GB, Pullen J, Moon T, Shuster J: CNS prophylaxis in acute lymphoblastic leukemia. Comparison of two methods. South West Oncology Group Study. Cancer, 1982; 50: 1031–36.
Freeman AJ, Weinberg V, Brecher ML, Jones B, Gliksman AS, Sinks LF, Weil M, Plüss HJ, Hananian J, Burgert DE, Gilchrist S, Necheles T, Harris M, Kung F, Patterson RB, Maurer H, Leventhal B, Chevalier L, Forman E, Holland JF: Comparison of intermediate methotrexate with cranial irradiation for the post-induction treatment of acute lymphocytic leukemia in children. N Engl J Med, 1983; 308: 477–84.
Does vd- Berg vd A, Hermans J, Nagel J, Steenis v G: Immunity of diphteria, pertussus, tetanus and poliomyelitis in children with acute lymphocytic leukemia after cessation of chemotherapy. Pediatrics, 1981; 67: 222–29.
Sallan SE, Weinstein HJ, Nathan DG: The childhood leukemia. Pediatr, 1981; 99: 676–88.
Dutcher JP, Schiffer CA, Aisner J, Wiernik PH: Longterm follow up of patients with leukemia receiving platelet transfusions: Identification of a large group of patients who do not become alloimmunized. Blood, 1981; 58: 1007–11.
Koning J de: Diagnostische en therapeutische aspecten van idiopathische thrombocytopenie. Academic Thesis, University of Leiden, Pasmans, The Hague, 1975: 52–53.
Koning J de: Platelet transfusion in bone marrow transplantation in children. In: Paediatrics and transfusion, Smit Sibinga CTh, Das PC, Forfar JO (eds). Martinus Nijhoff, The Hague, 1982: 228–36.
Schmitz N, Kayser W, Gassmann W, Huhn A, Kruger G, Sachs V, Loffler H: Two cases of graft versus host disease following transfusion of non irradiated blood products. Blut, 1982; 44: 83–88.
Lowenthal RM, Menon C, Challis DR: Graft versus host disease in consecutive patients with acute myeloid leukemia treated with blood cells from normal donors. Aust NZ J Med, 1981; 11: 179–83.
Kulpa J, Zaroulis CG, Good RA, Kutti J: Altered platelet function and circulation induced by amphotericin B in leukemic patients after platelet transfusion. Transfusion, 1981; 21: 74–76.
Winston DJ, Ho WG, Gale RP: Prophylactic granulocyte transfusions during chemotherapy of acute nonlymphocytic leukemia. Ann Intern Med, 1981; 94: 616–22.
Pflieger H, Arnold R, Bhaduri S, Dietrich M, Heimpel H. Kuh: ‘k B, Rasche H, Wiesneth M: Granulocyte transfusion in acute leukemia, regeneration of granulopoiesis as dcf°rmining factor of survival. Scand J Haematol, 1981; 26: 215–20.
Ford JM, Cohen MH, Roberts MM, Brown M, Oliver RT, Lister T: Prophylactic granulocyte transfusions. Results of a randomized controlled trial in patients with acute myelogenous leukemia. Transfusion, 1982; 22: 311–16.
Pochedley C: Infections in childhood leukemia. Clin Med, 1973; 80: 23–27.
Tobias JC, Wrigley PF, O’Grady G: Bacterial infection and acute myeloblastic leukemia, an analysis of two hundred patients undergoing intensive remission induction therapy. Eur J Cancer, 1978; 14: 383–91.
Siegel SE, Lipin S, Clerck de Y: Importance of gram positive bacterial infections during treatment for childhood leukemia (Meeting abstract). Clin Res, 1980; 28: 113.
Novak R, Feldman S: Salmonellosis in children with cancer. Am J Dis Child, 1979; 133: 298–300.
Newman KA, Schimpff SC, Young VM, Wiernik PH: Lessons learned from surveillance cultures in patients with acute nonlymphocytic leukemia, usefulness for epidemiologic, preventive and therapeutic research. Am J Med, 1981; 70: 423–31.
Fainstein V, Rodriguez V, Turuck M, Hermann G, Rosenbaum B, Bodey GP: Patterns of oropharyngeal and fecal flora in patients with acute leukemia. J Infect Dis, 1981; 144: 10–18.
Chessels JM, Leiper AD: Infection during remission induction in childhood leukemia. Arch Dis Child, 1980; 55: 1 1823.
Sleyfer DT, Mulder NH, Vries de-Hospers HG. Fidler V, Nieweg HO, Waay vdD, Saene vHK: Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Eur J Cancer, 1980; 16: 859–69.
Starke ID, Catovsky D, Johnson SA, Donelly P, Darrell J, Goldman JM, Galton DA: Co-trimoxazole alone for prevention of bacterial infection in patients with acute leukemia. Lancet, 1982; i 5–6.
Watson JG, Powles RL, Lawson DN, Morgenstern GR, Jameson B, McElwain TJ, Judson I, Lumley H, Kay HE: Co-trimoxazole versus non-absorbable antibiotics in acute leukemia. Lancet, 1982; i: 6–9.
Enno A, Darrell J, Hows J, Catovsky D, Goldman JM, Galton DA: Co-trimoxazole for prevention of infection in acute leukemia. Lancet, 1978; ii: 395–97.
Vries de-Hospers HG, Sleyfer DT, Mulder NH, Waayvd D, Nieweg HO, Saene vHKF: Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients. Antimicrobial Agents Chemother, 1981; 19: 813–20.
Kurrle E. Prevention of infection during induction therapy for acute leukemia. Klin Wochenschr, 1981; 59: 1075–79.
Smith IE, Powles R, Clink MD, Jameson B, Kay HE, McElwain TJ: Early deaths in acute myelogenous leukemia. Cancer, 1977; 39: 1710–14.
Bodey GP, Rodriguez V, Chang HY, Narboni G: Fever and infection in leukemic patients, a study of 494 consecutive patients. Cancer, 1978; 41: 1610–22.
Ninane J, Chessels JM: Serious infections during con-tinuing treatment of acute lymphoblastic leukaemia. Arch Dis Child, 1981; 56: 841–44.
Bussel A, Danon F, Ferchal F, Perot Y: Cytomegalovirus infection in malignant blood diseases: clinical and laboratory data in 29 patients. Nouv Rev Fr Hematol, 1978; 20: 67–76.
Cheeseman SH, Rinaldo CR, Hirsch MS: Use of interferon in cytomegalovirus infections in man. Tex Rep Biol Med, 1977; 35: 523–27.
Ruebush TK, Weinstein RA, Baehner RL, Wolff D, Barlett M, Gonzalez-Crussi F, Sulzer AJ, Schultz MG: An outbreak of Pneumocystis pneumonia in children with acute lymphocytic leukemia. Am J Dis Child, 1978; 132: 143–48.
Young LS: Trimethoprim-sulfamethoxazole in the treatment of adults with pneumonia due to Pneumocystis cariniï. Rev Infect Dis, 1984; 4: 608–13.
Ball F, Ulmer EM, Schuster W: Interstitial pneumonia in children with malignant diseases during intensive combined cytostatic therapy. Radiological manifestation and pathoanatomical findings. Klin Paed, 1978; 190: 83–93.
Morgan E: Decreased incidence of nonspecific interstitial pneumonitis in children with acute lymphocytic leukemia treated prophylactically with trimethoprim-sulfamethoxazole. J Pediatr, 1981; 99: 807–10.
Wilson JM, Guiney DG: Failure of oral trimethoprim-sulfamethoxazole in acute leukemia. Isolation of resistent plasmids from strains of enterobacteriaceae causing bacteremia. N Engl J Med, 1982; 306: 16–20.
Page CP, Coltman CA, Robertson HD, Nelson EA: Candi-dal abscess of the spleen in patients with acute leukemia. Surg Gynecol Obstet, 1980; 151: 604–8.
Menier-Carpentier F, Kiehn TE, Armstrong D: Fungemia in the immunocompromised host. Changing patterns, antiginemia, high mortality. Am J Med, 1981; 71: 363–70.
Pennington JE: Aspergillus pneumonia in hematologic malignancy: improvements in diagnosis and therapy. Arch Intern Med, 1977; 137: 769–71.
Rodriguez V, Bodey GP, Freireich EJ, McCredie KB, Gutterman JU, Keating MJ, Smith TL, Gehan EA: Ran-domized trial of protected environment-prophylactic antibiotics in 145 adults with acute leukemia. Med (Baltimore), 1978; 57: 253–66.
Vial R, Ryan D, Williams W, Bickers J: The value of protected environment (PE) in the management of acute leukemia (AL) in adults (meeting abstract). Clin Res, 1979; 27: 393.
Bhaduri S, Kurrle E, Krieger D, Plieger H, Arnold R, Kubanek B, Heimpel H: Infection prophylaxis in acute leukemia patients: Comparison of selective and total decontamination of the gastrontestinal tract. Folia Haematol. (Leipz). 1982; 109: 377–89.
Weel v.-Sipman MH, Meer vdJW, Koning deJ, Versteeg J: Severe atypical recurrent varicella in childhood leukemia. Lancet, 1981; i: 147–48.
Lopes A, Bianchi A, Gabriel Neto M, Franco PC, Morias VL: Varicella and herpes zoster associated with neoplasia of infancy. The use of cytosine arabinoside-C and gamma-globulin. Acta Oncol Bras, 1977; 1: 14–23.
Merigan TC, Rand KH, Pollard RB, Abdallah PS, Jordan GW, Fried RP: Human leucocyte interferon for the treatment of herpes zoster in patients with cancer. N Engl J Med, 1978; 298: 981–87.
Haas RJ, Janka G, Netzel B, Helmig M: Munich ALL 77–01 study of treatment of acute lymphocytic leukemia in childhood. Klin Paediatr, 1981; 193: 137–44.
Kubel M, Emmrich K, Helbig W, Schultze W, Ezold R, Delleman K, Schwenke H. Zentral venösel langzeitkatheter in der behandlung akuter leukämien: einführung einer modifikation der Hickman technik. Z Gesammte Inn Med, 1982; 37: 245–43.
Wade JC, Newman KA, Schimpff SC, Echo vDA, Gelber RA, Reed WP, Wiernik PH: Two methods for improved venous access in acute leukemia patients. JAMA, 1981; 246: 140–44.
Mulhern RK, Crisco JJ, Camitta BM: Patterns of communication among pediatric patients with leukemia, parents and physicians: Prognostic disagreements and misunderstandings. J Pediatr, 1981; 99: 480–83.
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De Koning, J., Halie, M.R. (1985). Supportive care in leukemia treatment. In: Das, P.C., Sibinga, C.T.S., Halie, M.R. (eds) Supportive therapy in haematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2577-2_20
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