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Supportive care in leukemia treatment

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Supportive therapy in haematology
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Abstract

The introduction of new cytostatic drugs and their clinical use in combination of radiotherapy and of bone marrow transplantation procedures have changed the clinical picture of leukemia. The prognosis for children with acute lymphoblastic leukemia (ALL) has already improved considerably since 1960. Nowadays, a first complete remission is achieved in 85 to 95% of these children with two to four drug induction schemes [1, 2, 3].

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References

  1. Pinkel D, Simone J, Hustu HO, Aur RJA: Nine years experience with total therapy of childhood lymphocytic leukemia. Pediatrics, 1972; 50: 246–5l.

    Google Scholar 

  2. Aur RJA, Simone JV, Venzosa MS, Hustu HO, Basker LF, Pinkel DP, Revira G, Hahl GV, Wood A, Stanger A, Mason C: Childhood acute lymphocytic leukemia. Cancer, 1978; 42: 2123–34.

    Article  PubMed  CAS  Google Scholar 

  3. Chessels JM: Acute lymphoblastic leukemia. Semin Hematol, 1982; 19: 155–71.

    Google Scholar 

  4. Haas RJ, Janka G, Netzel B, Helmig M: Munich ALL 77–01 study of treatment of acute lymphoblastic leukemia in childhood. Klin Pediatr, 1981; 193: 137–44.

    Article  CAS  Google Scholar 

  5. Simone JV, Verzosa MS, Rudy JA: Initial features and prognosis in 363 children with acute lymphocytic leukemia. Cancer, 1975; 36: 2009–2108.

    Google Scholar 

  6. Simone JV: Leukemia remission and survival. Lancet, 1981; 2: 531.

    Article  PubMed  CAS  Google Scholar 

  7. Vogler LB, Crist WM, Sariff AM, Pullen DJ, Bartolucci AA, Falletta JM, Dowell B, Humphrey GB, Blackstock R, Eys vG, Metzgar G, Cooper MD: An analysis of clinical and laboratory features of acute lymphocytic leukemias with emphasis on 35 children with pre B leukemia. Blood, 1981; 58: 135–40.

    PubMed  CAS  Google Scholar 

  8. Vries EGE de: Clinical and laboratory aspects of leukemia. Academic Thesis, University of Groningen, 1982; 26–40. Ed van Denderen, Groningen.

    Google Scholar 

  9. Evans AE, Gilbert ES, Zandstra R: The increasing incidence of central nervous system leukemia in children. Cancer, 1970; 26: 404–9.

    Article  PubMed  CAS  Google Scholar 

  10. Green DM, Freeman AI, Sather HS, Sallan SE, Nesbit ME, Cassady JR, Sinks LF, Hammond D, Frei E: Comparison of three methods of central nervous system prophylaxis in childhood acute lymphoblastic leukemia. Lancet, 1980; 1 1398–1402.

    Article  PubMed  CAS  Google Scholar 

  11. Nesbit ME, Sather HN, Robinson LL, Ortega J, Littman PS, d’Angio GJ, Hammond GD: Pre-symptomatic central nervous system therapy in previously untreated childhood acute lymphoblastic leukemia comparison of 1800 and 2400 Rad. A report for Children’s Cancer Study Group. Lancet, 1981; i: 461–65.

    Article  Google Scholar 

  12. Lister TA, Rohatiner AZ: Treatment of acute myelogenous leukemia in adults. Semin Hematol, 1982; 19: 17292.

    Google Scholar 

  13. Mayer RJ, Weinstein HJ, Rosenthal DS, Coral FS, Nathan DG, Frei E: VAPA; A treatment program for acute myelocytic leukemia. Haematol Blood Tansf, 1981; 26: 45–52.

    CAS  Google Scholar 

  14. Gale RP, Kay HE, Rimm AA, Bortin MM: Bone marrow transplantation for acute leukaemia in first remission. Lancet, 1982; ii: 1006–9.

    Article  Google Scholar 

  15. Barrett J, de Koning J: Supportive care in bone marrow transplantation. In: Supportive Therapy in Haematology, Das PC, Smit Sibinga CTh, Halie MR (eds). Martinus Nijhoff, Boston, 1985.

    Google Scholar 

  16. Thomas ED: The role of marrow transplantation in the eradication of malignant disease. Cancer, 1982; 49: 1963–69.

    Article  PubMed  CAS  Google Scholar 

  17. Spiers ASD, Booth AE, Frith JL: Subcutaneous cerebrospinal reservoirs in patients with acute leukemia. Scand Haematol, 1978; 20: 289–96.

    Article  CAS  Google Scholar 

  18. Klose HJ, Kelson S, Schwarzbach K, Janka G, Netzel B, Haas R, Betke K: Initial treatment of acute childhood leukemia with extreme leucocytosis by blood exchange transfusion: rheological aspects. Klin Paediatr, 1981; 193: 172–76.

    Article  CAS  Google Scholar 

  19. Drapkin RL, Gee TS, Dowling MD, Arlin Z, McKenzie S, Kempin S, Clarkson B: Prophylactic heparintherapy in acute promyelocytic leukemia. Cancer, 1978; 41: 2484–90.

    Article  PubMed  CAS  Google Scholar 

  20. Bauer TW, Haskins GE, Armitage JD: Splenic rupture in patients with haematological malignancies. Cancer, 1981; 48: 2729–33.

    Article  PubMed  CAS  Google Scholar 

  21. Cervantes F: Tumour lysis syndrom with hypocalciaemia in accelerated chronic granulocytic leukaemia. Acta Haemat, 1982; 68: 157–59.

    Article  PubMed  CAS  Google Scholar 

  22. Young RC, Ozolo RF, Myers CE: The anthracycline antineoplastic drugs. N Engl J Med, 1981; 305: 139–53.

    Article  PubMed  CAS  Google Scholar 

  23. Billingham ME, Mason JW, Bristow MR, Daniels JR: Anthracycline cardiomyopathy monitored by morphological changes. Cancer Treat Rep, 1978; 62: 865–72.

    PubMed  CAS  Google Scholar 

  24. Steinherz PG, Miller LP, Ghavimi F, Allen JC, Miller DR: Dural sinus thrombosis in children with acute lymphoblastic leukemia. JAMA, 1981; 246: 2837–39.

    Article  PubMed  CAS  Google Scholar 

  25. Simone J: Acute lymphoblastic leukemia in childhood. Semin Haematol, 1974; 11: 25–39.

    CAS  Google Scholar 

  26. Komp DM, Fernandes CH, Falletta JM, Ragab AH, Humphrey GB, Pullen J, Moon T, Shuster J: CNS prophylaxis in acute lymphoblastic leukemia. Comparison of two methods. South West Oncology Group Study. Cancer, 1982; 50: 1031–36.

    Article  PubMed  CAS  Google Scholar 

  27. Freeman AJ, Weinberg V, Brecher ML, Jones B, Gliksman AS, Sinks LF, Weil M, Plüss HJ, Hananian J, Burgert DE, Gilchrist S, Necheles T, Harris M, Kung F, Patterson RB, Maurer H, Leventhal B, Chevalier L, Forman E, Holland JF: Comparison of intermediate methotrexate with cranial irradiation for the post-induction treatment of acute lymphocytic leukemia in children. N Engl J Med, 1983; 308: 477–84.

    Article  PubMed  CAS  Google Scholar 

  28. Does vd- Berg vd A, Hermans J, Nagel J, Steenis v G: Immunity of diphteria, pertussus, tetanus and poliomyelitis in children with acute lymphocytic leukemia after cessation of chemotherapy. Pediatrics, 1981; 67: 222–29.

    Google Scholar 

  29. Sallan SE, Weinstein HJ, Nathan DG: The childhood leukemia. Pediatr, 1981; 99: 676–88.

    Article  CAS  Google Scholar 

  30. Dutcher JP, Schiffer CA, Aisner J, Wiernik PH: Longterm follow up of patients with leukemia receiving platelet transfusions: Identification of a large group of patients who do not become alloimmunized. Blood, 1981; 58: 1007–11.

    PubMed  CAS  Google Scholar 

  31. Koning J de: Diagnostische en therapeutische aspecten van idiopathische thrombocytopenie. Academic Thesis, University of Leiden, Pasmans, The Hague, 1975: 52–53.

    Google Scholar 

  32. Koning J de: Platelet transfusion in bone marrow transplantation in children. In: Paediatrics and transfusion, Smit Sibinga CTh, Das PC, Forfar JO (eds). Martinus Nijhoff, The Hague, 1982: 228–36.

    Google Scholar 

  33. Schmitz N, Kayser W, Gassmann W, Huhn A, Kruger G, Sachs V, Loffler H: Two cases of graft versus host disease following transfusion of non irradiated blood products. Blut, 1982; 44: 83–88.

    Article  PubMed  CAS  Google Scholar 

  34. Lowenthal RM, Menon C, Challis DR: Graft versus host disease in consecutive patients with acute myeloid leukemia treated with blood cells from normal donors. Aust NZ J Med, 1981; 11: 179–83.

    Article  CAS  Google Scholar 

  35. Kulpa J, Zaroulis CG, Good RA, Kutti J: Altered platelet function and circulation induced by amphotericin B in leukemic patients after platelet transfusion. Transfusion, 1981; 21: 74–76.

    Article  PubMed  CAS  Google Scholar 

  36. Winston DJ, Ho WG, Gale RP: Prophylactic granulocyte transfusions during chemotherapy of acute nonlymphocytic leukemia. Ann Intern Med, 1981; 94: 616–22.

    PubMed  CAS  Google Scholar 

  37. Pflieger H, Arnold R, Bhaduri S, Dietrich M, Heimpel H. Kuh: ‘k B, Rasche H, Wiesneth M: Granulocyte transfusion in acute leukemia, regeneration of granulopoiesis as dcf°rmining factor of survival. Scand J Haematol, 1981; 26: 215–20.

    Article  PubMed  CAS  Google Scholar 

  38. Ford JM, Cohen MH, Roberts MM, Brown M, Oliver RT, Lister T: Prophylactic granulocyte transfusions. Results of a randomized controlled trial in patients with acute myelogenous leukemia. Transfusion, 1982; 22: 311–16.

    Article  PubMed  CAS  Google Scholar 

  39. Pochedley C: Infections in childhood leukemia. Clin Med, 1973; 80: 23–27.

    Google Scholar 

  40. Tobias JC, Wrigley PF, O’Grady G: Bacterial infection and acute myeloblastic leukemia, an analysis of two hundred patients undergoing intensive remission induction therapy. Eur J Cancer, 1978; 14: 383–91.

    PubMed  CAS  Google Scholar 

  41. Siegel SE, Lipin S, Clerck de Y: Importance of gram positive bacterial infections during treatment for childhood leukemia (Meeting abstract). Clin Res, 1980; 28: 113.

    Google Scholar 

  42. Novak R, Feldman S: Salmonellosis in children with cancer. Am J Dis Child, 1979; 133: 298–300.

    PubMed  CAS  Google Scholar 

  43. Newman KA, Schimpff SC, Young VM, Wiernik PH: Lessons learned from surveillance cultures in patients with acute nonlymphocytic leukemia, usefulness for epidemiologic, preventive and therapeutic research. Am J Med, 1981; 70: 423–31.

    Article  PubMed  CAS  Google Scholar 

  44. Fainstein V, Rodriguez V, Turuck M, Hermann G, Rosenbaum B, Bodey GP: Patterns of oropharyngeal and fecal flora in patients with acute leukemia. J Infect Dis, 1981; 144: 10–18.

    Article  PubMed  CAS  Google Scholar 

  45. Chessels JM, Leiper AD: Infection during remission induction in childhood leukemia. Arch Dis Child, 1980; 55: 1 1823.

    Google Scholar 

  46. Sleyfer DT, Mulder NH, Vries de-Hospers HG. Fidler V, Nieweg HO, Waay vdD, Saene vHK: Infection prevention in granulocytopenic patients by selective decontamination of the digestive tract. Eur J Cancer, 1980; 16: 859–69.

    Google Scholar 

  47. Starke ID, Catovsky D, Johnson SA, Donelly P, Darrell J, Goldman JM, Galton DA: Co-trimoxazole alone for prevention of bacterial infection in patients with acute leukemia. Lancet, 1982; i 5–6.

    Article  Google Scholar 

  48. Watson JG, Powles RL, Lawson DN, Morgenstern GR, Jameson B, McElwain TJ, Judson I, Lumley H, Kay HE: Co-trimoxazole versus non-absorbable antibiotics in acute leukemia. Lancet, 1982; i: 6–9.

    Article  Google Scholar 

  49. Enno A, Darrell J, Hows J, Catovsky D, Goldman JM, Galton DA: Co-trimoxazole for prevention of infection in acute leukemia. Lancet, 1978; ii: 395–97.

    Article  Google Scholar 

  50. Vries de-Hospers HG, Sleyfer DT, Mulder NH, Waayvd D, Nieweg HO, Saene vHKF: Bacteriological aspects of selective decontamination of the digestive tract as a method of infection prevention in granulocytopenic patients. Antimicrobial Agents Chemother, 1981; 19: 813–20.

    Google Scholar 

  51. Kurrle E. Prevention of infection during induction therapy for acute leukemia. Klin Wochenschr, 1981; 59: 1075–79.

    Article  PubMed  CAS  Google Scholar 

  52. Smith IE, Powles R, Clink MD, Jameson B, Kay HE, McElwain TJ: Early deaths in acute myelogenous leukemia. Cancer, 1977; 39: 1710–14.

    Article  PubMed  CAS  Google Scholar 

  53. Bodey GP, Rodriguez V, Chang HY, Narboni G: Fever and infection in leukemic patients, a study of 494 consecutive patients. Cancer, 1978; 41: 1610–22.

    Article  PubMed  CAS  Google Scholar 

  54. Ninane J, Chessels JM: Serious infections during con-tinuing treatment of acute lymphoblastic leukaemia. Arch Dis Child, 1981; 56: 841–44.

    Article  PubMed  CAS  Google Scholar 

  55. Bussel A, Danon F, Ferchal F, Perot Y: Cytomegalovirus infection in malignant blood diseases: clinical and laboratory data in 29 patients. Nouv Rev Fr Hematol, 1978; 20: 67–76.

    PubMed  CAS  Google Scholar 

  56. Cheeseman SH, Rinaldo CR, Hirsch MS: Use of interferon in cytomegalovirus infections in man. Tex Rep Biol Med, 1977; 35: 523–27.

    PubMed  CAS  Google Scholar 

  57. Ruebush TK, Weinstein RA, Baehner RL, Wolff D, Barlett M, Gonzalez-Crussi F, Sulzer AJ, Schultz MG: An outbreak of Pneumocystis pneumonia in children with acute lymphocytic leukemia. Am J Dis Child, 1978; 132: 143–48.

    PubMed  Google Scholar 

  58. Young LS: Trimethoprim-sulfamethoxazole in the treatment of adults with pneumonia due to Pneumocystis cariniï. Rev Infect Dis, 1984; 4: 608–13.

    Article  Google Scholar 

  59. Ball F, Ulmer EM, Schuster W: Interstitial pneumonia in children with malignant diseases during intensive combined cytostatic therapy. Radiological manifestation and pathoanatomical findings. Klin Paed, 1978; 190: 83–93.

    CAS  Google Scholar 

  60. Morgan E: Decreased incidence of nonspecific interstitial pneumonitis in children with acute lymphocytic leukemia treated prophylactically with trimethoprim-sulfamethoxazole. J Pediatr, 1981; 99: 807–10.

    Article  PubMed  CAS  Google Scholar 

  61. Wilson JM, Guiney DG: Failure of oral trimethoprim-sulfamethoxazole in acute leukemia. Isolation of resistent plasmids from strains of enterobacteriaceae causing bacteremia. N Engl J Med, 1982; 306: 16–20.

    Article  PubMed  CAS  Google Scholar 

  62. Page CP, Coltman CA, Robertson HD, Nelson EA: Candi-dal abscess of the spleen in patients with acute leukemia. Surg Gynecol Obstet, 1980; 151: 604–8.

    PubMed  CAS  Google Scholar 

  63. Menier-Carpentier F, Kiehn TE, Armstrong D: Fungemia in the immunocompromised host. Changing patterns, antiginemia, high mortality. Am J Med, 1981; 71: 363–70.

    Article  Google Scholar 

  64. Pennington JE: Aspergillus pneumonia in hematologic malignancy: improvements in diagnosis and therapy. Arch Intern Med, 1977; 137: 769–71.

    Article  PubMed  CAS  Google Scholar 

  65. Rodriguez V, Bodey GP, Freireich EJ, McCredie KB, Gutterman JU, Keating MJ, Smith TL, Gehan EA: Ran-domized trial of protected environment-prophylactic antibiotics in 145 adults with acute leukemia. Med (Baltimore), 1978; 57: 253–66.

    CAS  Google Scholar 

  66. Vial R, Ryan D, Williams W, Bickers J: The value of protected environment (PE) in the management of acute leukemia (AL) in adults (meeting abstract). Clin Res, 1979; 27: 393.

    Google Scholar 

  67. Bhaduri S, Kurrle E, Krieger D, Plieger H, Arnold R, Kubanek B, Heimpel H: Infection prophylaxis in acute leukemia patients: Comparison of selective and total decontamination of the gastrontestinal tract. Folia Haematol. (Leipz). 1982; 109: 377–89.

    CAS  Google Scholar 

  68. Weel v.-Sipman MH, Meer vdJW, Koning deJ, Versteeg J: Severe atypical recurrent varicella in childhood leukemia. Lancet, 1981; i: 147–48.

    Google Scholar 

  69. Lopes A, Bianchi A, Gabriel Neto M, Franco PC, Morias VL: Varicella and herpes zoster associated with neoplasia of infancy. The use of cytosine arabinoside-C and gamma-globulin. Acta Oncol Bras, 1977; 1: 14–23.

    Google Scholar 

  70. Merigan TC, Rand KH, Pollard RB, Abdallah PS, Jordan GW, Fried RP: Human leucocyte interferon for the treatment of herpes zoster in patients with cancer. N Engl J Med, 1978; 298: 981–87.

    Article  PubMed  CAS  Google Scholar 

  71. Haas RJ, Janka G, Netzel B, Helmig M: Munich ALL 77–01 study of treatment of acute lymphocytic leukemia in childhood. Klin Paediatr, 1981; 193: 137–44.

    Article  CAS  Google Scholar 

  72. Kubel M, Emmrich K, Helbig W, Schultze W, Ezold R, Delleman K, Schwenke H. Zentral venösel langzeitkatheter in der behandlung akuter leukämien: einführung einer modifikation der Hickman technik. Z Gesammte Inn Med, 1982; 37: 245–43.

    CAS  Google Scholar 

  73. Wade JC, Newman KA, Schimpff SC, Echo vDA, Gelber RA, Reed WP, Wiernik PH: Two methods for improved venous access in acute leukemia patients. JAMA, 1981; 246: 140–44.

    Article  PubMed  CAS  Google Scholar 

  74. Mulhern RK, Crisco JJ, Camitta BM: Patterns of communication among pediatric patients with leukemia, parents and physicians: Prognostic disagreements and misunderstandings. J Pediatr, 1981; 99: 480–83.

    Article  PubMed  CAS  Google Scholar 

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De Koning, J., Halie, M.R. (1985). Supportive care in leukemia treatment. In: Das, P.C., Sibinga, C.T.S., Halie, M.R. (eds) Supportive therapy in haematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2577-2_20

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