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Abstract

Regardless of the site of infection, pathogenic microbes may enter the bloodstream and cause septic shock, which is a life-threatening syndrome characterized by hypotension, inadequate tissue perfusion, hypoxia, and metabolic acidosis. Circulatory insufficiency is initiated by bacteremia or by by-products of killed bacteria that cause cellular injury, activation of complement and coagulation, and release of vasoactive compounds. A presumptive diagnosis of septic shock is made when hypotension is preceded by chills and fever in association with tachycardia, tachypnea, oliguria, or mental obtundation.

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References

  1. Cates W Jr, Rochat RW, Grimes DA, et al: Legalized abortion: Effect on national trends of maternal and abortion-related mortality (1940 through 1976). Am J Obstet Gynecol 132: 211–214, 1978

    PubMed  Google Scholar 

  2. Blanco JD, Gibbs RS, Castaneda YS: Bacteremia in obstetrics: Clinical course. Obstet Gynecol 58: 621–625, 1981

    Google Scholar 

  3. Ledger WJ, Norman M, Gee C, et al: Bacteremia on an obstetric-gynecologic service. Am J Obstet Gynecol 121: 205–212, 1975

    PubMed  CAS  Google Scholar 

  4. Wolff SM, Bennett JV: Gram-negative rod bacteremia. N Engl J Med 291: 733–734, 1974

    Article  PubMed  CAS  Google Scholar 

  5. Altemeier WA, Cole WR: Nature and treatment of septic shock. Arch Surg 77: 498–507, 1958

    CAS  Google Scholar 

  6. Finland M: Changing ecology of bacterial infections as related to antibacterial therapy. J Infect Dis 122: 419–431, 1970

    Article  PubMed  CAS  Google Scholar 

  7. Kreger BE, Craven DE, Carling PC, et al: Gram-negative bacteremia. III. Reassessment of etiology, epidemiology and ecology in 612 patients. Am J Med 68: 332–343, 1980

    Article  PubMed  CAS  Google Scholar 

  8. Petersdorf RG, Dale DC: Gram-negative bacteremia in septic shock, in Isselbacher KJ, Adams RD, Braunwald E, et al (eds): Harrison’s Principles of Internal Medicine, ed 9. New York, McGraw-Hill, 1980, pp 561–566

    Google Scholar 

  9. Gilstrap LC, Cunningham FG: The bacterial pathogenesis of infection following cesarean section. Obstet Gynecol 53: 545–549, 1979

    PubMed  Google Scholar 

  10. Schumer W: Steroids in the treatment of clinical septic shock. Ann Surg 184: 333–341, 1976

    Article  PubMed  CAS  Google Scholar 

  11. Ziegler EJ, McCutchan JA, Fierer J, et al: Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli. N Engl J Med 307: 1225–1230, 1982

    Article  PubMed  CAS  Google Scholar 

  12. Polin JI, Knox I, Baumgart S, et al: Use of umbilical cord blood for culture for detection of neonatal bacteremia. Obstet Gynecol 57: 233–237, 1981

    PubMed  CAS  Google Scholar 

  13. Campbell LV Jr, Gilbert EF: Experimental giant-cell transformation in the liver induced by E. coli endotoxin. Am J Pathol 51: 855 - 868, 1967

    PubMed  Google Scholar 

  14. Leviton A, Gilles F: Maternal urinary-tract infections and fetal leukoencephalopathy [Letter to the Editor]. N Engl J Med 301: 661, 1979

    PubMed  CAS  Google Scholar 

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© 1985 Plenum Publishing Corporation

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Cunningham, F.G., Leveno, K.J. (1985). Bacteremia and Septic Shock. In: Gleicher, N. (eds) Principles of Medical Therapy in Pregnancy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2415-7_45

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  • DOI: https://doi.org/10.1007/978-1-4613-2415-7_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9471-9

  • Online ISBN: 978-1-4613-2415-7

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