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Polymer Properties Associated with Calcification of Cardiovascular Devices

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Calcium in Biological Systems

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Abstract

Nucleation and growth of calcium phosphate crystals on blood pumps designed to assist or replace the natural heart is a limiting factor in the long-term survival of experimental animals. This phenomenon, first reported by Olsen et al. [24] in 1975, is an acknowledged problem in all cardiovascular implant centers with routine animal survival times greater than 100 days[8]. The exact cause of the deposition of calcium phosphate, crystallization, and growth is not known, but several factors have been identified as important participants in the process. These factors will be discussed in some detail below.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutics, University of Utah, Salt Lake City, Utah, 84112, USA

    Dennis L. Coleman, Hwei-Chuen Hsu & David E. Dong

  2. Department of Surgery, Division of Artificial Organs, University of Utah, Salt Lake City, Utah, 84112, USA

    Donald B. Olsen

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  1. Dennis L. Coleman
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  2. Hwei-Chuen Hsu
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  3. David E. Dong
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  4. Donald B. Olsen
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Editor information

Editors and Affiliations

  1. Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Ronald P. Rubin  & James W. Putney Jr.  & 

  2. CIBA-GEIGY Corporation, Summit, New Jersey, USA

    George B. Weiss

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© 1985 Plenum Press, New York

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Coleman, D.L., Hsu, HC., Dong, D.E., Olsen, D.B. (1985). Polymer Properties Associated with Calcification of Cardiovascular Devices. In: Rubin, R.P., Weiss, G.B., Putney, J.W. (eds) Calcium in Biological Systems. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2377-8_71

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  • DOI: https://doi.org/10.1007/978-1-4613-2377-8_71

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9453-5

  • Online ISBN: 978-1-4613-2377-8

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