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Molecular Genetics of Tyrosine Hydroxylase

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Role of RNA and DNA in Brain Function

Part of the book series: Topics in the Neurosciences ((TNSC,volume 3))

Abstract

The isolation of tyrosine hydroxylase (TH) cDNA clones has allowed the determination of the entire amino acid sequence of this previously uncharacterized protein. Amino acid sequence comparison with phenyl-alanine hydroxylase indicates that these enzymes share a high degree of homology. The human TH gene maps to the short arm of chromosome 11. The changes in TH mRNA and enzyme after reserpine injection have been analyzed. Their possible significance as to the mechanism of TH induction is discussed. Finally, new developments have concerned the detection of TH mRNA in tissue sections and the analysis of the TH nuclear gene.

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Author information

Authors and Affiliations

  1. Laboratoire de Neurobiologie Cellulaire et Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

    J. Mallet, F. Blanot, C. Boni, N. Faucon Biguet, B. Grima, Ph. Horellou, J.-F. Julien, A. Lamouroux & J. Powell

  2. Institut National de la Santé et de la Recherche Médicale, Hôpital Ste-Eugénie, Saint-Genis-Laval, France

    A. Berod & M. Buda

Authors
  1. J. Mallet
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  2. A. Berod
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  3. F. Blanot
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  4. C. Boni
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  5. M. Buda
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  6. N. Faucon Biguet
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  7. B. Grima
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  8. Ph. Horellou
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  9. J.-F. Julien
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  10. A. Lamouroux
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  11. J. Powell
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Editor information

Editors and Affiliations

  1. Department of General and Environmental Physiology, University of Naples, Italy

    Antonio Giuditta

  2. Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, USA

    Barry B. Kaplan

  3. Office of Naval Research London Branch, UK

    Claire Zomzely-Neurath

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© 1986 Martinus Nijhoff Publishing

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Mallet, J. et al. (1986). Molecular Genetics of Tyrosine Hydroxylase. In: Giuditta, A., Kaplan, B.B., Zomzely-Neurath, C. (eds) Role of RNA and DNA in Brain Function. Topics in the Neurosciences, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2321-1_6

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  • DOI: https://doi.org/10.1007/978-1-4613-2321-1_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-89838-814-5

  • Online ISBN: 978-1-4613-2321-1

  • eBook Packages: Springer Book Archive

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