Abstract
Breast cancer is genetic, in the sense that breast tumor development is initiated by alterations—mutations, somatic recombinations, duplications, and so on—of DNA sequences in breast epithelial cells. These alterations may be inherited in the germ line, or may be due to somatic events induced by environmental mutagens. If an alteration is inherited in the germ line in a family, then an unusually large number of breast cancer cases are likely to appear in that family. If inherited alterations are common, then breast cancer will tend to cluster in families.
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© 1986 Martinus Nijhoff Publishing, Boston
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King, M.C. (1986). Of Mice and Women: Genetic Analysis of Breast Cancer In Families. In: Rich, M.A., Hager, J.C., Taylor-Papadimitriou, J. (eds) Breast Cancer: Origins, Detection, and Treatment. Developments in Oncology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2309-9_19
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DOI: https://doi.org/10.1007/978-1-4613-2309-9_19
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