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Behavioral Effects of Antimitotic Agents Administered during Neurogenesis

  • Chapter
Handbook of Behavioral Teratology

Abstract

The agents to be discussed in this chapter were among the first to be identified as behavioral teratogens. Their effects on behavior have been reviewed several times, most recently by Vorhees and Butcher (1982). Therefore, to say something new on the subject, it is necessary to elaborate on other aspects of the effects of these agents. This is not an inappropriate theme because, unlike some behavioral teratogens, these first attracted attention because of their ability to cause gross malformations and/or specific brain pathology. Of course, evidence of long-lasting injury to the developing brain is available for many agents, including ethanol (Abel, Jacobson, & Sherwin, 1983; Barnes & Walker, 1981), diazepam (Simmons, Kellogg, & Miller, 1984), and methylmercury (Sager, Aschner, & Rodier, 1984), but for antimitotics, we have more than a list of pathological changes observed after treatment. We have some insight into the nature of the initial injury, into the variables determining its characteristics, and into its expression in morphology and function in adults. With this information, some of the effects of antimitotic agents are orderly and predictable—words that can rarely be applied in teratology.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642, USA

    Patricia M. Rodier

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  1. Patricia M. Rodier
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Editors and Affiliations

  1. Department of Psychology, State University of New York at Albany, Albany, New York, USA

    Edward P. Riley

  2. Institute for Developmental Research, Children’s Hospital Research Foundation, Cincinnati, Ohio, USA

    Charles V. Vorhees

  3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    Charles V. Vorhees

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Rodier, P.M. (1986). Behavioral Effects of Antimitotic Agents Administered during Neurogenesis. In: Riley, E.P., Vorhees, C.V. (eds) Handbook of Behavioral Teratology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2189-7_9

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