Abstract
The complexity of haematoporphyrin derivative (HPD) either in total or as its aggregate fraction (Photofrin II) has meant that many studies of the effects of this material, both in vitro and in vivo, have been by comparison with other porphyrins and by deduction from the behaviour of these porphyrins, particularly haematoporphyrin (HP) and protoporphyrin (PP). Many of our studies on these materials, particularly those involving chemistry and solution behaviour, have indicated that HPD, HP and PP show a remarkably wide variation in their physical and chemical properties and that they are particularly different from each other in aqueous solution. Of these three porphyrins HP is the most “normal” in its properties and the one which shows the expected behaviour in aqueous solution. It is appropriate therefore to discuss it first and then to compare and contrast other species with it and with each other.
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© 1985 Plenum Press, New York
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Ward, A.D., Swincer, A.G. (1985). The Structure of Protoporphyrin and of the Aggregate Fraction of Haematoporphyrin Derivative in Solution. In: Kessel, D. (eds) Methods in Porphyrin Photosensitization. Advances in Experimental Medicine and Biology, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2165-1_26
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DOI: https://doi.org/10.1007/978-1-4613-2165-1_26
Publisher Name: Springer, Boston, MA
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