Abstract
For about twenty years, benzimidazole drugs have enjoyed wide commercial applications as systemic fungicides, as broad spectrum anthelmintics against cestode and nematode infections, and as antitumoral agents. The range of benzimidazole derivatives that became available was limited only by the resources of the drug firms, and the skill of the organic chemists. The effectiveness of these drugs is well established: they have performed well in field and clinical trials, and are commercially successful. However, it is only recently, and certainly within the last ten years that the mechanism of their action has been studied in any systematic way. Basic science is now catching up to commercial pragmatism!!
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References
Atkinson, C., Newsam, R. J. and Gull, K., 1980, Influence of the anti-microtubule agent, mebendazole, on the secretory activity of intestinal cells of Ascaridia galli, Protoplasma, 105: 69–76.
Burland, T. G. and Gull, K., 1984, Molecular and cellular aspects of the interaction of benzimidazole fungicides with tubulin and microtubules, in: “Mode of Action of Antifungal Agents,” A.P.J. Trinci and J.P. Ryley Teds.), British Mycological Symposium, pp. 299–320, Cambridge University Press, Cambridge.
Burland, T. G., Schedl, T., Gull, K. and Dove, W. E., 1984, Genetic analysis of resistance to benzimidazoles in Physarum: differential expression of 8-tubulin genes, Genetics, 108: 123–141.
Cabral, F., Sobel, M. E. and Gottesman, M. M., 1980, CHO mutants resistant to colchicine, colcemid, or griseofulvin have an altered B-tubulin, Cell, 20: 29–36.
Cappucinelli, P., Fighetti, M. and Rubino, S., 1979, Amitotic inhibitor for chromosomal studies in slime molds, FEMS Microbiol Letters, 5: 25–27.
Clayton, L., Quinlan, R. A., Roobol, A., Pogson, C. I. and Gull, K., 1980, A comparison of tubulins from mammalian brain and Physarum polycephalum using SDS-polyacrylamide gel electrophoresis and peptide mapping, FEBS Lett., 115: 301–305.
Hastie, A. C., 1970, Benlate-induced instability of Aspergillus diploids, Nature, 266: 771–772.
Hoebeke, J., Van Nijen, G. and DeBrabander, M., 1976, Tnteraction of oncadazole (R17934), a new anti-tumoral drug, with rat brain tubulin, Biochem. Biophys. Res. Commun., 69: 319–324.
Howard, R. J. and Aist, J. R., 19/7, Effects of MBC on hyphal tip organisation growth and mitosis of Fusarium acuminatum, and their antagonism by D20, Protoplasma, 92: 195–210.
Ireland, C. M., Clayton, L. Gutteridge, W. E., Pogson, C. I. and Gull, K., 1982, Identification and drug binding capabilities of tubulin in the nematode Ascaridia galli, Molec. Biochem. Parasitol., 6: 45–53.
Kilmartin, J. Y., 1981, PurificationlvF yeast tubulin by self-assembly in vitro, Biochemistry 20: 3629–3633.
Mareel, M., Storme, G., Debrijyne, G. and Van Cauwenberge, R., 1980, Anti-invasive effect of microtubule inhibitors in vitro, in: “Microtubules and Microtubule Inhibitors 1980,”H.UeSrabander and J. DeMey (eds.), pp. 534–544, Elsevier North-Holland, Oxford.
Morris, N. R., 1980, The genetics of microtubule polymerization and the mechanism of action of antimicrotubule drugs in Aspergillus nidulans, in: “Microtubules and Microtubule Inhibitors 1980,” M. DeBrabander and TT DeMey (eds.), pp. 511–521, Elsevier North-Holland, Oxford.
Styles, J. A. and Garner, R., 1974, Benzimidazole carbamate methyl ester- evaluation of effects in vivo and in vitro, Mutation Res., 26: 177–187.
Wagner, E. D. and Chavarria, A. P., 19/4, In vivo effects of a new anthelmintic, mebendazole (R-17635), on the eggs of Trichuris trichiura and hookworm, Ann. J. Trop. Med. Hyg.,, 23:151–159.
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© 1986 Plenum Press, New York
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Byard, E.H., Gull, K. (1986). Molecular and Cellular Aspects of the Interaction of Benzimidazole Carbamate Pesticides with Microtubules. In: Clarkson, T.W., Sager, P.R., Syversen, T.L.M. (eds) The Cytoskeleton. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2161-3_6
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DOI: https://doi.org/10.1007/978-1-4613-2161-3_6
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