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Herpesvirus Sylvilagus: Lymphoproliferative Agent of Cottontail Rabbits

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Virus Diseases in Laboratory and Captive Animals

Part of the book series: Developments in Veterinary Virology ((DVVI,volume 6))

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Abstract

Herpesvirus sylvilagus is an indigenous virus of cottontail rabbits. Infection of rabbits results in a lymphoproliferative disorder characterized by spleen and lymph node hyperplasia, the appearance of atypical lymphocytes in the peripheral blood, and an intense T-cell proliferation. In vivo, the virus is present latently in B and T lymphocytes in both a covalently closed circular form and a linear duplex form. In vitro, the virus is able to bind to lymphocytes but a productive infection is not detected. In productively infected cultured rabbit kidney cells, the virus induces the synthesis of at least 45 virus-induced polypeptides of which at least 14 are glycosylated.

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Author information

Authors and Affiliations

  1. Department of Medical Microbiology, University of Wisconsin Medical School, Madison, WI, 53706, USA

    Amy K. Patick & Harry C. Hinze

Authors
  1. Amy K. Patick
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  2. Harry C. Hinze
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Editor information

Editors and Affiliations

  1. Institute für Medizinische Virologie der universität Heidelberg, Federal Republic of Germany

    Gholamreza Darai

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© 1988 Martinus Nijhoff Publishers, Boston

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Patick, A.K., Hinze, H.C. (1988). Herpesvirus Sylvilagus: Lymphoproliferative Agent of Cottontail Rabbits. In: Darai, G. (eds) Virus Diseases in Laboratory and Captive Animals. Developments in Veterinary Virology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2091-3_14

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  • DOI: https://doi.org/10.1007/978-1-4613-2091-3_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9239-5

  • Online ISBN: 978-1-4613-2091-3

  • eBook Packages: Springer Book Archive

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