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Nicotinic Regulation of Sympathoadrenal Catecholamine Secretion: Cross-Tolerance to Stress

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Tobacco Smoking and Nicotine

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 31))

Abstract

The effects of nicotine on the regulation of sympathoadrenal secretion have long been recognized (1,2). Recent demonstration of endogenous opioid peptides colocalized with catecholamines in the adrenal medulla and in sympathetic nerve terminals has provided new impetus for the further study of both the physiologic regulation of sympathoadrenal secretion by nicotinic cholinergic receptors and the pharmacologic effects of this alkaloid (3,4). In addition to actions on adrenal chromaffin cells and sympathetic ganglia (5), it is thought that nicotine may stimulate sympathoadrenal secretion of catecholamines and opioid peptides by acting in brain to increase central sympathetic outflow. However, the latter issue has not been established, and we have initiated a series of studies comparing plasma catecholamine and cardiovascular responses to peripheral (intraarterial; ia) versus central (intraventricular; ivt) administration of nicotine.

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Author information

Authors and Affiliations

  1. Department of Medicine, University of Kentucky VA Medical Center, Lexington, KY, 40511, USA

    Glen R. Van Loon, Judith A. Kiritsy-Roy, Laura V. Brown & Frances A. Bobbitt

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  1. Glen R. Van Loon
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  2. Judith A. Kiritsy-Roy
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  3. Laura V. Brown
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  4. Frances A. Bobbitt
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Kentucky, Lexington, Kentucky, 40536, USA

    William R. Martin

  2. Department of Medicine, Veterans Administration Medical Center University of Kentucky, Lexington, Kentucky, 40511, USA

    Glen R. Van Loon

  3. Department of Pharmacology College of Medicine, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  4. The Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 40536, USA

    Edgar T. Iwamoto

  5. Tobacco and Health Research Institute, University of Kentucky, Lexington, Kentucky, 04546-0236, USA

    Layten Davis (Director) (Director)

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© 1987 Plenum Press, New York

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Van Loon, G.R., Kiritsy-Roy, J.A., Brown, L.V., Bobbitt, F.A. (1987). Nicotinic Regulation of Sympathoadrenal Catecholamine Secretion: Cross-Tolerance to Stress. In: Martin, W.R., Van Loon, G.R., Iwamoto, E.T., Davis, L. (eds) Tobacco Smoking and Nicotine. Advances in Behavioral Biology, vol 31. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1911-5_16

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  • DOI: https://doi.org/10.1007/978-1-4613-1911-5_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9063-6

  • Online ISBN: 978-1-4613-1911-5

  • eBook Packages: Springer Book Archive

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