Abstract
Murine coronaviruses, including MHV-A59, MHV-3, and JHM, have a neurotropic potential in rodents causing either an acute fatal encephalitis or a paralytic disease (Bailey et al., 1949; Lampert et al., 1973; Le Provost et al., 1975; Hirano et al., 1980; Knobler et al, 1981b). Central nervous system (CNS) infection of mice may result from intracerebral (IC) or intraperitoneal (IP) inoculation of a number of these coronaviruses, which have tropisms for various CNS cells including glia and neurons (Virelizier et al., 1975; Fleury et al., 1980; Knobler et al., 1981a). By contrast, in rats overt CNS symptoms are associated exclusively with JHM virus (JHMV) (Hirano et al., 1980; Sorensen et al., 1980). An IC inoculation of MHV-3 into rats may result in virus replication without overt symptoms of disease (Hirano et al., 1980; our unpublished data), implying that this strain replicates in cells that are not critical for CNS function, at least as judged by clinical criteria. Although MHV-3 infection of the rat CNS appears to be transitory, JHMV RNA can be identified in the CNS of some asymptomatic animals several months post-inoculation (Sorensen et al., 1984). It remains to be established whether, under these circumstances, JHMV persists at low titers as an infectious entity or enters into a truly latent state.
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Keywords
- Demyelinating Disease
- Central Nervous System Tissue
- Central Nervous System Cell
- Mouse Hepatitis Virus
- Wistar Furth
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References
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Sorensen, O., Beushausen, S., Coulter-Mackie, M., Adler, R., Dales, S. (1987). In Vivo and in Vitro Models of Demyelinating Disease. In: Kurstak, E., Lipowski, Z.J., Morozov, P.V. (eds) Viruses, Immunity, and Mental Disorders. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1799-9_18
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DOI: https://doi.org/10.1007/978-1-4613-1799-9_18
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