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The role of epidermal growth factor in normal and neoplastic growth of mouse mammary epithelial cells

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Breast Cancer: Cellular and Molecular Biology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 40))

Abstract

Epidermal growth factor (EGF) was discovered by Cohen in 1962 [1] as the principal in extracts of male mouse submandibular gland which produced acceleration of incisor eruption and eyelid opening when administered to newborn mice. It has since been purified to homogeneity and sequenced [2]. Mouse EGF is a single-chain polypeptide (mol. wt. 6045) containing 53 amino acid residues and 3 disulfide linkages. EGF is also present in biological fluids such as plasma, saliva, milk, urine, amniotic fluid, sweat, pancreatic juice, and cerebrospinal fluid [3–5]. EGF exhibits diverse biological actions, influencing proliferation, differentiation, and functional activities of various types of mammalian cells [3–6]. EGF has also been a useful tool for the analysis of receptor hormone interactions and receptor mediated endocytosis of polypeptide hormones. Several excellent reviews of the chemistry and biology of EGF have been published [3–7].

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Authors
  1. Takami Oka
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  2. Osamu Tsutsumi
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  3. Hirohisa Kurachi
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  4. Shigeru Okamoto
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Editor information

Editors and Affiliations

  1. National Cancer Institute, USA

    Marc E. Lippman  & Robert B. Dickson  & 

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© 1988 Kluwer Academic Publishers, Boston/Dordrecht/London

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Oka, T., Tsutsumi, O., Kurachi, H., Okamoto, S. (1988). The role of epidermal growth factor in normal and neoplastic growth of mouse mammary epithelial cells. In: Lippman, M.E., Dickson, R.B. (eds) Breast Cancer: Cellular and Molecular Biology. Cancer Treatment and Research, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1733-3_16

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  • DOI: https://doi.org/10.1007/978-1-4613-1733-3_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8975-3

  • Online ISBN: 978-1-4613-1733-3

  • eBook Packages: Springer Book Archive

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