Skip to main content

Reversible Effects of Focused Ultrasound on Myocardium

  • Chapter
Pathophysiology and Pharmacology of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 102))

  • 56 Accesses

Abstract

Ultrasound pulse-echo imaging systems seem to be one field in which ultrasound is used in cardiology. In echocardiography ultrasound plays the role of a signal for investigation of the heart. Until recently, little attention has been paid to the effects of ultrasound on heart tissues. The two main effects on biological tissue are heating and mixing of internal media. These effects have been demonstrated in experiments on all tissues including nerve and muscle. Though the use of therapeutic ultrasound is contraindicated in cardiac diseases,1 the mechanism of its effect on the heart is poorly understood. In particular, except in the recent past, there has been little or no work on the influence of acoustic cavitation which may be caused by some diagnostic ultrasound systems during heart examinations.2,3

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. ter Haar GR, Dyson M, Oakley EM. The use of ultrasound by physiotherapists in Britain. Ultrasound in Med Biol 1987;13:659–663.

    Article  Google Scholar 

  2. Crum LA, Fowlkes JB. Acoustic cavitation generated by microsecond pulses of ultrasound. Nature 1986;319:52–54.

    Article  Google Scholar 

  3. Miller DL A review of the ultrasonic bioeffects of microsonation, gas-body activation, and related cavitation — like phenomena. Ultrasound in Med Biol 1987;13:443–470.

    Article  CAS  Google Scholar 

  4. Morton KI, ter Haar GR, Startford IJ and Hill CR. Subharmonic emission as an indicator of ultrasonically – induced biological damage. Ultrasound in Med Biol 1983;9:629–633.

    Article  CAS  Google Scholar 

  5. Carstensen EL Acoustic cavitation and the safety of diagnostic ultrasound. Ultrasound in Med Biol 1987;13:597–606.

    Article  CAS  Google Scholar 

  6. Forester GV, Roy OZ, Mortimer AJ. Enhancement of contractility in rat isolated papillary muscle with therapeutic ultrasound. J Mol Cell Cardiol 1982;14:475–477.

    Article  PubMed  CAS  Google Scholar 

  7. Forester GV, Roy OZ, Mortime AJ. Ultrasound intensity and contractile characteristics of rat isolated papillary muscle. Ultrasound in Med Biol 1985;11:591–598.

    Article  CAS  Google Scholar 

  8. Mortimer AJ, Trollope BJ. Altered myocardial contractility with pulsed ultrasound. Ultrasound in Med Biol 1987;13:L567–L569.

    Google Scholar 

  9. Flynn HG. Generation of transient cavities inliquids subjected to microsecond pulses of ultasound. J Acoust Soc Am 1982;72:1926–1932.

    Article  Google Scholar 

  10. Young RR, Henneman E. Functional effects of focused ultrasound on mammalian nerve. Neurology 1961;11:1521–1522.

    Google Scholar 

  11. Talbert DG. Spontaneous smooth muscle activity as a means of detecting biological effects of ultrasound. In Proceedings of Ultrasonics International Conference. 1975:279–284. Imperial College, London.

    Google Scholar 

  12. Smailys S, Dulevicius Z, Muckus K. and Dauksa K. Investigation of the possibilities of cardiac efibrillation by ultrasound. Resuscitation 1981;9:23–242.

    Article  Google Scholar 

  13. Deleze J. The recovery of resting potential and input resistance in sheep heart injured by knife or laser. J Physiol (Lond) 1970;208:547–562.

    CAS  Google Scholar 

  14. Deleze J. Cell-to-Cell communication in the heart: structure-function correlations. Experientia 1987;43:1068–1074.

    Article  PubMed  CAS  Google Scholar 

  15. De Mello WC. Cell-to-Cell coupling assayed by means of electrical measurements. Experientia 1987;43:1075–1079.

    Article  PubMed  Google Scholar 

  16. Schouten V, ter Keurs HED. The slow repolarisation phase of the action potential in rat Heart J Physiol (Lond) 1985;360:13–25.

    CAS  Google Scholar 

  17. Champman IV, Mac Nally NA, Tucker S. Ultrasound induced changes in rates of efflux of potassium ions in rat thymocytes in vitro. Ultrasound in Med Biol 1980;6:47–58.

    Article  Google Scholar 

  18. Yuk-Chow NG, Hume JR, Akera T. Paradoxical positive inotropic effect of K + in the rat heart. Amer J Physiol 1987;252:H1005–H1015.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Bogdanov, K.Y., Zakhrov, S.I., Rosenshtraukh, L.V. (1989). Reversible Effects of Focused Ultrasound on Myocardium. In: Anand, I.S., Wahi, P.L., Dhalla, N.S. (eds) Pathophysiology and Pharmacology of Heart Disease. Developments in Cardiovascular Medicine, vol 102. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1607-7_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1607-7_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8889-3

  • Online ISBN: 978-1-4613-1607-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics