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Oncogenes in human leukemias and lymphomas

  • Chapter
Oncogenes

Part of the book series: Cancer Treatment and Research ((CTAR,volume 47))

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Abstract

Hematologic malignancies frequently have been used as model systems in the study of tumorigenesis owing to the ease of isolating neoplastic tissue and to the wealth of knowledge on the growth and differentiation of the hematopoietic elements. Since malignancy is due to perturbations in the control of growth and differentiation, it is hoped that identifying genetic elements that induce leukemias may also point to those factors that control normal cellular functions. Proto-oncogenes represent such genetic elements; they have important functions in normal cells but can be perturbed to become cancer-causing genes. In this chapter, we will examine the role of various oncogenes in the development of human hematopoietic malignancies, and will discuss them in two groups (see table 1): oncogenes with strong associations with the human leukemias and lymphomas (seen frequently and consistently in the human disease), and those with limited associations with the human disorders (seen occasionally in humans, but whose role in leukemogenesis and lympho-magenesis is suggested by association or is certain in animal systems). Tumor-suppressor genes also appear to be important participants in the malignant progression of these hematopoietic neoplasms. However, since specific leukemia/lymphoma-suppressor genes have not been isolated, they will be discussed in a separate section.

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  1. Edison Liu
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  1. Cancer Research Institute, University of California, San Francisco, USA

    Christopher Benz

  2. Lineberger Cancer Research Center, The University of North Carolina at Chapel Hill, USA

    Edison Liu

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Liu, E. (1989). Oncogenes in human leukemias and lymphomas. In: Benz, C., Liu, E. (eds) Oncogenes. Cancer Treatment and Research, vol 47. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1599-5_10

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