Abstract
For many years physiologists have sought to understand the movement of plasma proteins across the endothelial surface of small blood vessels by applying the physical principles of diffusion and convection to geometric models of small particles and semipermeable membranes. The endothelium has been viewed as a continuous surface containing water-filled channels or “pores” large enough to allow the passage of plasma proteins but small enough to restrict their passage relative to water. The plasma proteins, in turn, have been viewed as inert particles that move through the pores at a rate proportionate to their size and the hydrostatic and oncotic pressure gradients across the endothelium
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© 1988 Plenum Press, New York
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Hansen-Flaschen, J.H., Fishman, A.P. (1988). Studies of Pulmonary Endothelial Permeability Using Tritiated Dextrans. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Biology in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0937-6_5
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DOI: https://doi.org/10.1007/978-1-4613-0937-6_5
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