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Assessment of Interstitial Fluid Adenosine: Implications for Exogenous and Endogenous Adenosine-Mediated Cardioprotection

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Purines and Myocardial Protection

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 181))

  • 51 Accesses

Abstract

This chapter focuses on a specific aspect of the cardioprotective properties of adenosine, namely how the sampling of myocardial interstitial fluid (ISF) and the estimate of the changes in ISF adenosine provides insight into the protective actions of adenosine. As such, this chapter will concentrate on adenosine itself, both endogenously produced as well as exogenously administered, and will describe the effectiveness of certain pharmaceutical strategies designed to augment endogenous ISF adenosine. Because of the emphasis on the assessment of ISF adenosine, the wealth of important and interesting data dealing with pharmacological agents which are cardioprotective due to their direct actions at the adenosine receptor will not be discussed in this chapter.

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Author information

Authors and Affiliations

  1. Department of Biology, St. Olaf College, Northfield, Minnesota, USA

    David G. L. Van Wylen

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  1. David G. L. Van Wylen
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Editors and Affiliations

  1. Cardiothoracic Division, Department of Surgery, Box 890532, MCV Station, Richmond, VA, 23298-0532, USA

    Anwar-Saad A. Abd-Elfattah MS, Ph.D.

  2. Department of Surgery, Medical College of Virginia, Richmond, Virginia, 23298-0532, USA

    Andrew S. Wechsler M.D.

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© 1996 Kluwer Academic Publishers

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Van Wylen, D.G.L. (1996). Assessment of Interstitial Fluid Adenosine: Implications for Exogenous and Endogenous Adenosine-Mediated Cardioprotection. In: Abd-Elfattah, AS.A., Wechsler, A.S. (eds) Purines and Myocardial Protection. Developments in Cardiovascular Medicine, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0455-5_5

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  • DOI: https://doi.org/10.1007/978-1-4613-0455-5_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8056-6

  • Online ISBN: 978-1-4613-0455-5

  • eBook Packages: Springer Book Archive

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