Abstract
The ATP-sensitive potassium channel (KATP) was first discovered by Noma (1) in 1983 in guinea pig ventricular myocytes using patch clamp methodology. Noma demonstrated that intracellular concentrations of ATP ranging from 25–200 µM. resulted in a concentration-dependent inhibition of KATP channel opening. Subsequently, this channel has also been shown to exist in various other tissues including pancreatic beta cells, skeletal muscle, vascular smooth muscle and the central nervous system (2).
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© 1996 Kluwer Academic Publishers
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Gross, G.J., Yao, Z., Auchampach, J.A. (1996). KATP Channels, Adenosine Receptors and Ischemic Preconditioning. In: Abd-Elfattah, AS.A., Wechsler, A.S. (eds) Purines and Myocardial Protection. Developments in Cardiovascular Medicine, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0455-5_29
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DOI: https://doi.org/10.1007/978-1-4613-0455-5_29
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