Abstract
A decisive step forward in human cytogenetics was the discovery of banding techniques that reveal distinctive and reproducible patterns of transverse bands along the chromosomes. These permit accurate identification of all the chromosomes, recognition of a host of structural rearrangements, and identification of the breakpoints in most of these. Chromosome bands have great theoretical and practical significance. They are fundamental units of chromosome organization and play a key role in gene regulation, as described in Chapter 7. They have made possible the rapid identification of an enormous range of karyotype abnormalities and the construction of increasingly comprehensive physical and genetic linkage maps of the chromosomes. New banding techniques continue to enrich our understanding of the complex human genome. Banding techniques and their applications have been reviewed extensively (for example, Verma and Babu, 1995; Bickmore and Craig, 1997).
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Miller, O.J., Therman, E. (2001). Chromosome Bands. In: Human Chromosomes. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-0139-4_6
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DOI: https://doi.org/10.1007/978-1-4613-0139-4_6
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