Abstract
With the exception of the rare tumors of the umbilical cord, only two tumorous processes occur in the placenta, one of which, the chorioangioma, may not represent a true neoplasm. In contrast, the chorionepithelioma or choriocarcinoma is a truly malignant neoplasm of the chorionic epithelium, the trophoblast. In most reports dealing with neoplasms of the placenta, particularly the larger reviews (Briquel; Meyer; Hertig & Mansell; Smalbraak), the hydatidiform mole is also included as a tumorous condition. We do not share this view, but regard the molar swelling of villi as a degenerative change and the occasional sequel, the development of a choriocarcinoma, as a basically unrelated outcome of this degeneration. To accentuate this distinction, we have chosen to separate these conditions in this review and hope that it will serve to promote investigation designed to elucidate the possible etiologic connections between the two processes.
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References
Barry, F. E., C. P. Mccoy & W. P. Callahan, Jr.: Hemangioma of umbilical cord. Amer. J. Obstet. Gynec. 62, 675 (1951).
Beneke, R.: Ein Fall von Chorionangiom. Verh. deutsch. Path. Ges. 2, 407 (1900).
Benirschke, K., & G. L. Bourne: Plasma cells in an immature placenta. Obstet. Gynec. 12, 495 (1958).
Benson, P. F., & M. C. Joseph: Cardiomegaly in a newborn due to placental ehorioangioma. Brit. Med. J. i, 102 (1961).
BRIQUEL, P.: Tumeiirs du Placenta et Tumeurs Plaeentaires (Placentomes malins). C. Naud, Paris, 1903.
Cary, W. H.: Report of a well-authenticated case of sarcoma of the placenta. Amer. J. Obstet. 69, 658 (1914).
Clarke, J.: Account of a tumor found in the substance of the human placenta. Philosoph. Trans. 88, 361 (1798).
Cohen, M. I., & J. C. Sinclair: Neonatal death from congestive heart failure associated with large cutaneous cavernous hemangioma. Pediatrics 32, 924 (1963).
Conway, D. F., Jr., & R. Barone: Hemangioma of the placenta: Report of a case. Obstet. Gynec. 19, 505 (1962).
Corcoran, C. J. & E. C. Murphy: Rare bovine placental tumour A case report. Vet. Ree. 77, 1234 (1965).
Corkill, T. F.: Infant’s vulnerable life line. Austral. New Zealand J. Obstet. Gynaec 1, 154 (1961).
Decosta, E. J., A. B. Gerbie, R. H. Andresen & T. C. Gallanis: Placental tumors: hemangiomas with special reference to an associated clinical syndrome. Obstet. Gynec. 7, 249 (1956).
Dienst, A.: Quoted by BRIQUEL and STRAKOSCH. DUNN, R. I. S.: Haemangioma of placenta (chorio-angioma); report of 9 cases. J. Obstet. Gynaec. Brit. Emp. 66, 51 (1959).
Earn, A. A., & D. W. Penner: Five cases of chorioangioma. J. Obstet. Gynaec. Brit. Emp. 57, 442 (1950).
Fisher, J. H.: Chorioangioma of the placenta. Amer. J. Obstet. Gynec. 40, 493 (1940).
Gruenwald, P.: Chronic fetal distress and placental insufficiency. Biol. Neonat. 5, 215 (1963).
Heggtveit, H. A., R. D. Carvalho & A. J. Nuyens: Chorioangioma and toxemia of pregnancy. Amer. J. Obstet. Gynec. 91, 291 (1965).
Hertig, A. T., & H. Mansell: Tumors of the Female Sex Organs. Part. I. Hydatidi- form Moles and Choriocarcinoma. A.F.I.P. Atlas of Tumor Pathology. Armed Forces Institute of Pathology, Washington 1956.
Hörmann, G.: Zur Systematik einer Pathologie der menschlichen Placenta. Arch. Gynäk. 191, 297 (1958).
HYRTL, J.: Die Blutgefäße der menschlichen Nachgeburt in normalen und abnormen Verhältnissen. Braumüller, Wien, 1870.
Javert, C. T.: Spontaneous and Habitual Abortion. Blakiston, McGraw-Hill Co. N.Y. 1957.
Klaften, E.: Chorionhaemangioma placentae. Z. Geburtsh. Gynäk. 95, 426 (1929).
Kühnel, P.: Placenta chorioangioma. Acta obstet, et gynec. Scandinav. 13, 143 (1933).
Mcinroy, R. A., & H. A. Kelsey: Chorioangioma (haemangioma of placenta) associated with acute hydramnios. J. Path. Bact. 68, 519 (1954).
Marchetti, A. A.: Consideration of certain types of benign tumors of placenta. Surg. Gynec. Obstet. 68, 733 (1939).
Meyenburg, H.: Über Hemangiomatosis diffusa Placentae. Beitr. path. Anat. allg. Path. 70, 510 (1922).
Meyer, R.: Plazentatumoren. Geburtsh. Gynäk. 86, 419 (1923).
PLENTL, A.: The origin of amniotic fluid. Gestation, 4th Conference, p. 71–114.
Josiah Macy, Jr. Foundation, N. Y. 1958.
Potter, E. L.: Pathology of the Fetus and the Infant. Year Book Medical Publ. Chicago 1961 (2nd Ed.).
Reiner, L., & E. Fries: Chorangioma associated with arteriovenous aneurysm. A study on hamartoma. Amer. J. Obstet. Gynec. 93, 58 (1965).
Sidall, R. S.: The occurrence of chorioangiofibroma (chorioangioma); a study of six hundred placentas. Johns Hopkins Hosp. Bull., Bait., 38, 355 (1926).
Smalbraak, J.: Trophoblastic Growths. Hydatidiform Mole and Chorionepithelioma. Elsevier Co., Amsterdam 1957.
Smith, D. W.: The No. 18 trisomy and D1-trisomy syndromes. Pediatric Clinics North Amer. 10, 389 (1963).
Strakosch, W.: Über Chorionangiome. Geburtsh. u. Frauenh. 16, 485 (1956).
Sulman, F. G., & E. Sulman: Increased gonadotrophin production in a case of detachment of placenta due to placental haemangioma. J. Obstet. Gynaec. Brit.Emp. 56, 1033 (1949).
Thomas, J.: Die gestörte Vaskularisation der menschlichen Plazenta und ihre Auswirkungen auf die Frucht. Geburtsh. Frauenheilk. 19, 801 (1959).
Wentworth, P.: The incidence and significance of haemangioma of the placenta. J. Obstet. Gynaec. Brit. Cwlth. 72, 81 (1965).
Williams, J. T.: Angioma of the placenta; with pathological report and mierophoto- graphs by Frank B. Mallory. Surg. Gynec. Obstet. 32, 523 (1921).
Acosta-sison, H.: The relationship of hydatidiform mole to preeclampsia and eclampsia. A study of 85 cases. Amer. J. Obstet. Gynec. 71, 1279 (1956).
— Editorial. Etiology of preeclampsia-eclampsia and the role of hydatidiform mole. Obstet. Gynec. 9, 233 (1957).
— Indications for immediate hysterectomy without curettage in cases of hydatidiform mole. Amer. J. Obstet. Gynec. 80, 176 (1960).
— Influence of pulmonary tuberculosis on hydatidiform mole. Obstet. Gynec. 20, 103 (1962).
— Changing attitudes in the management of hydatidiform mole. Amer. J. Obstet. Gynec. 88, 634 (1964).
Alter, M. N., & S. A. Cosgrove: Hydatidiform mole; practical considerations. Obstet. Gynec. 5, 755 (1955).
Aramburu, G.: Memorias del II Congreso latinamerieano de Obstetricia y Ginecologia (Cited by Marquez-Monter, et al), Es. Aso. mex. ginec. y obst. (1958).
Arnold, H. A., & A. R. Bainborough: Subacute cor pulmonale following trophoblastic pulmonary embolism. Can. Med. Ass. J. 76, 478 (1957).
Atkin, N. B., and H. P. Klinger: The superfemale mole. Lancet ii, 727 (1962).
Attwood, H. D., and W. W. Park: Embolism to the lungs by trophoblast. J. Obstet. Gynaec. Brit. Cwlth. 68, 611 (1961).
Azar, H.A.: Consanguinity: a possible etiological factor in choriocarcinoma. Transcript of the Second Rochester Trophoblast Conference. Edited by Lund, C. J., & H. A. Thiede, Department of Obstetrics and Gynecology of the University of Rochester School of Medicine and Dentistry, Rochester, New York, 1963.
Bagshawe, K. D.: Trophoblastic tumours. Chemotherapy and developments. Brit. Med. J. ii, 1303 (1963).
— Hydatidiform mole and choriocarcinoma. Brit. Med. J. i, 1509 (1964).
E. S. Garnett: Radiological changes in the lungs of patients with trophoblastic tumors. Brit. J. Radiol. 36, 673 (1963).
Bardawil, W. A., A. T. Hertig, & J. T. Velardo: Regression of trophoblast. I. Hydatidiform mole; a case of unusual features, possibly metastasis and regression; review of literature. Obstet. Gynec. 10, 614 (1957).
B. L. Toy: The natural history of choriocarcinoma: problems of immunity and spontaneous regression. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 197 (1959).
Barkla, P. C.: Hydatidiform mole and chorionepithelioma. J. Obstet. Gynaec. Brit. Emp. 62, 239 (1955).
Beischer, N. A.: Hydatidiform mole with co-existent foetus. J. Obstet. Gynaec. Brit. Cwlth. 68, 231 (1961).
Bobrow, M. L., & S. Friedman: Hydatidiform mole in 12-year-old girl. Amer. J. Obstet. Gynec. 73, 448 (1957).
Borell, U., I. Fernström, K. Lindblom, & A. Westman: Diagnostic value of arteriography of iliac artery in gynaecology and obstetrics. Acta Radiol. 38, 247 (1952).
— Hydatidiform mole diagnosed by pelvic angiography. Acta Radiol. 56, 113 (1961).
Bowles, H. E.: Extensive hydatidiform mole formation with living child. Amer. J. Obstet. Gynec. 46, 154 (1943).
Brewer, J. I.: The Albert F. Mathieu Chorionepithelioma Registry. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 140 (1959).
Personal communication from Albert Mathieu Chorionepithelioma Registry to Gore, H. M., & A. T. Hertig, 1961.
A. B. Gerbie, R. E. Dolkart, J. H. Skom, & E. E. Torok: Chemotherapy in trophoblastic diseases. Amer. J. Obstet. Gynec. 90, 566 (1964).
Brews, A.: Hydatidiform mole and chorion-epithelioma. J. Obstet. Gynaec. Brit. Emp. 46, 813 (1939).
Bromberg, Y. M., M. Salzberger, & A. Abrahamov: Alkali resistant type of hemoglobin in women with molar pregnancy. Blood 12, 1122 (1957).
Brown, D. B.: A case of coexisting hydatidiform mole and living child. J. Obstet. Gynaec. Brit. Emp. 64, 446 (1957).
Bur, G. E., A. T. Hertig, D. G. May, & E. C. Adams: Histochemical aspects of hydatidiform mole and choriocarcinoma. Obstet. Gynec. 19, 156 (1962).
Burgoin, P., R. Baylet & C. Ballon: Etudes des chromosomes de la grossesse molaire. Compt. rend. Soc. Biol. 159, 957 (1965).
Buxton, C. L.: Management of patients with hydatidiform mole. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 121 (1959).
Canlas, B. D., Jr.: Classification and transitions in chorionic tumors. Acta Med. Philippina 15, 223 (1959).
— Benign lesions of aberrant trophoblasts in the lungs. Obstet. Gynec. 20, 602 (1962).
Chalmers, J. A.: Hydatidiform mole in the fallopian tube. J. Obstet. Gynaec. Brit. Emp. 55, 322 (1948).
Chamberlain, G.: Hydatidiform mole in twin pregnancy. Amer. J. Obstet. Gynec. 87, 140 (1963).
Chesley, L. C., S. A. Cosgrove, & J. Preece: Hydatidiform mole with special reference to recurrence and associated eclampsia. Amer. J. Obstet. Gynec. 52, 311 (1946).
Cockshott, W. P., K. T. E. Evans, & J. P. Dev. Hendrickse: Arteriography of trophoblastic tumors. Clin. Radiol. 15, 1 (1964).
Coppleson, M.: Hydatidiform mole and its complications. J. Obstet. Gynaec. Brit. Emp. 65, 238 (1958).
Corscaden, J. A., & L. B. Shettles: Hydatidiform mole and choriocarcinoma. Bull. Sloane Hosp. Women. 5, 41 (1959).
Das, P. C.: Hydatidiform mole: a statistical and clinical study. J. Obstet. Gynaec. Brit. Emp. 45, 265 (1938).
Delfs, B. E.: Quantitative chorionic gonadotrophin—prognostic value in hydatidiform mole and chorionepithelioma. Obstet. Gynec. 9, 1 (1957).
Delfs, E.: Chorionic gonadotrophin determinations in patients with hydatidiform mole and choriocarcinoma. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 125 (1959).
Dolff, C.: Über Abortiveier. Diskussion. Zbl. Gynäk. 67, 1074 (1943).
— Unterschiedliche Befunde an den Zotten und der Decidua bei Aborten und ihre klinische Bedeutimg. Arch. Gynäk. 175, 319 (1944).
Donald, I., & T. G. Brown: Localisation using physical devices, radioisotopes and radiologic methods. I. Demonstration of tissue interfaces within the body by ultrasonic echo sounding. Brit. J. Radiol. 34, 539 (1961).
Douglas, G. W.: The diagnosis and management of hydatidiform mole. S. Clin. North America 37, 379 (1957).
— Malignant change in trophoblastic tumors. Amer. J. Obstet. Gynec. 84, 884 (1962).
L. Thomas, M. Carr, N. M. Gullen & R. Morris: Trophoblast in the circulating blood during pregnancy. Amer. J. Obstet. Gynec. 78, 960 (1959).
Edmonds, H. W.: Genesis of hydatidiform mole: old and new concepts. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 86 (1959).
Endres, R. J.: Hydatidiform mole. Report of a patient with 5 consecutive hydatidi- form moles. Amer. J. Obstet. Gynec. 81, 711 (1961).
Englund, S., & E. Odeblod: Uterusrupturer under graviditet och forlössning vid tumörer, endometrios och mola hydatidosa. Nord. Med. 44 1992 (1950).
Ewing, J.: Neoplastic Diseases; a Treatise on Tumors. Philadelphia, 1940, W. B. Saunders Co., pp. 608–623.
Fahrner, R. J., A. J. Mcqueeney, J. M. Moseley & R. W. Petersen: Trophoblastic pulmonary thrombosis with cor pulmonale. J.A.M.A. 170, 1898 (1959).
Girouard, D. P., D. L. Barclay & C. G. Collins: Hyperreactio luteinalis. Obstet. Gynec. 23, 513 (1964).
Grady, H. G.: Hydatidiform mole and choriocarcinoma. Ann. N. Y. Acad. Sci. 75, 565 (1959).
Greene, R. R.: Chorioadenoma destruens. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 143, 1959.
Haines, M., & C. W. Taylor: Gynaecological Pathology. Boston, Little, Brown and Company, 1962.
Harnden, D. G.: Congenital abnormalities with an apparently normal chromosome complement. In: Conference on Human Chromosomal Abnormalities. Proceedings, London, 1959. Edited by Davidson, W. M. & Smith, D. R. London, Staples Press, 1961, p. 123.
Harper, W. F., & J. Mac vicar: Hydatidiform mole and pregnancy diagnosed by sonar. Brit. Med. J. ii, 1178 (1963).
De V. Hendrickse, J. P., W. P. Cockshott, K. T. E. Evans & C. T. Barton: Pelvic angiography in the diagnosis of malignant trophoblastic disease. New Engl. J. Med. 271, 859 (1964).
Hertig, A. T.: Angiogenesis in the early human chorion and in the primary placenta of the macacque monkey. Contrib. Embryol. Carnegie Inst. Wash. 25 (146): 37 (1935).
— Hydatidiform mole and chorionepithelioma. In: Meigs, J. V., & S. H. Sturgis, Editors: Progress in Gynecology, New York, 1950, Grune and Stratton, Inc., chapter 7.
H. W. Edmonds: Genesis of hydatidiform mole. Arch. Path. 30, 260 (1940).
W. H. Sheldon: Hydatidiform mole — A pathologico-clinical correlation of 200 cases. Amer. J. Obstet. Gynec. 53, 1 (1947).
H. Mansell: Tumors of the Female Sex Organs. Part I. Hydatidiform mole and choriocarcinoma. Armed Forces Institute of Pathology, Washington, D. C., 1956.
Hertz, R., D. M. Bergenstal, M. B. Lipsett, E. B. Price & T. F. Hilbish: Chemotherapy of choriocarcinoma and related trophoblastic tumors in women. J.A.M.A. 168, 845 (1958).
— Chemotherapy of choriocarcinoma and related trophoblastic tumors in women. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 262 (1959).
R. H. Moy: Effect of Vincaleukoblastine on metastatic choriocarcinoma and related trophoblastic tumors in women. Cancer Res. 20, 1050 (1960).
J. Lewis Jr. & M. B. Lipsett: Five years’ experience with the chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Amer. J. Obstet. Gynec. 82, 631 (1961)
G. T. Ross & M. B. Lipsett: Primary chemotherapy of nonmetastatic trophoblastic disease in women. Amer. J. Obstet. Gynec. 86, 808 (1963).
— Chemotherapy in women with trophoblastic disease: Choriocarcinoma, chorioadenoma destruens, and complicated hydatidiform mole. Ann. N. Y. Acad. Sci. 114, 881 (1964).
Highman, J. H., & D. Sutton: Angiography in hydatidiform mole and chorion epithelioma. Clin. Radiol. 15, 9 (1964).
Hobson, B. M.: The excretion of chorionic gonadotrophin in normal pregnancy and in women with hydatidiform mole. J. Obstet. Gynaec. Brit. Emp. 62, 354 (1955).
— Further observations on the excretion of chorionic gonadotrophin by women with hydatidiform mole. J. Obstet. Gynaec. Brit. Emp. 65, 253 (1958).
Hopman, B. C., & D. Cavanagh: Cytology of hydatidiform mole. Amer. J. Obstet. Gynec. 92, 274 (1965).
Hsu, C. T., L. C. Huang & T. Y. Chen: Metastases in benign hydatidiform mole and chorioadenoma destruens. Amer. J. Obstet. Gynec. 84, 1412 (1962).
C. S. Lai, C. L. Changchien & B. C. Changchien: Repeat hydatidiform moles. Amer. J. Obstet. Gynec. 87, 543 (1963).
Huber, C. P., J. R. Melin & F. Vellios: Changes in chorionic tissue of aborted pregnancy. Amer. Obstet. Gynec. 73, 569 (1957).
Hughes, J. E.: A case of hydatidiform mole with multiple small syncytial infarcts of the lung. Proc. Roy. Soc. Med. 23, 1151 (1929).
Hunt, W., M. B. Dockerty & L. M. Randall: Hydatidiform mole: a clinicopatholo- gic study involving “grading” as a measure of possible malignant change. Obstet. Gynec. i, 593 (1953).
Jacobson, F. J., & N. Enzer: Hydatidiform mole with “benign” metastasis to lung — histological evidence of regressing lesion in lung. Amer. J. Obstet. Gynec. 78,868 (1959).
— Joint Project for Study of Choriocarcinoma and Hydatidiform mole in Asia: Geographic variation in the occurrence of hydatidiform mole and choriocarcinoma. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 178 (1959).
Kaeser, O.: Studien an menschlichen Aborteiern mit besonderer Berücksichtigimg der frühen Fehlbildungen und ihrer Ursachen. Schweiz. Med. Wschr. 79, 509 (1949).
Kassjanow, Zur Frage über die Lungen — embolie von riesenkernhaltigen Zellen. Inaug. – Diss. St. Petersburg, 1896. Cited by Schmorl.
Kika, K., & I. Matuda: Primary tubal hydatidiform mole. Obstet. Gynec. 9, 224
King, G.: Hydatidiform mole and chorion-epithelioma — the problem of the borderline case. Proc. Roy. Soc. Med. 49, 381 (1956).
Kirschbaum, H.: Hydatid degeneration of the placenta. Correspondence. Amer. J. Obstet. Gynec. 76, 466 (1958).
Kittermaster, A. R., & P. Stallabrass: Hydatidiform mole misdiagnosed as choriocarcinoma. Brit. Med. J. i, 1228 (1964).
Klinger, H. P.: Points from the discussion. Human Chromosomal Abnormalities. Proceedings, London, 1959. Edited by Davidson, W. M., & D. R. Smith, London, Staples Press, 1961, p. 130.
N. B. Atkin: Sex chromatin studies on hydatidiform moles. Human Chromosome Newsletter 3, 18 (1961).
Kohl, G. C.: Hydatidiform mole and a four and one-half month fetus. Amer. J. Obstet. Gynec. 79, 1091 (1959).
Krone, H. A.: Blasenmole mit einem ausgetragenen lebenden Kind. Zbl. Gynäk. 77, 1391 (1955).
Laffont, A., H. M. Fulconis & J. Perret-bony: A propos d’une série de trois case de môle hydatiforme embryonée. Bull. Féd. Soc. Gynec. Obstet. de Langue Franc. 4, 348 (1952).
Larsen, J. F.: Electron microscopy of the human placenta. Transcript of the Second Rochester Trophoblast Conference, p. 280. Edited by Lund, C. J., & H. A. Thiede. Department of Obstetrics and Gynecology, of the University of Rochester School of Medicine and Dentistry, Rochester, New York (1963).
Lazarus, J. A., & A. Schifrin: An unusual case of benign multiple chorionic villi implants in peritoneal cavity accompanied by hemoperitoneum. Ann. Surg. 115, 93 (1942).
Lee, A. T., & I. Siegel: Hydatidiform mole with rupture of the uterus. Obstet. Gynec. 26, 133 (1965).
Leeder, J. R.: Metastasizing hydatidiform mole. Amer. J. Obstet. Gynec. 88, 833 (1964).
Li, M. C., R. Hertz & D. B. Spencer: Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proc. Soc. Exper. Biol. Med. 93, 361 (1956).
D. M. Bergenstal: Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists. New Engl. J. Med. 259, 66
Lipp, R. G., J. D. Kindschi & R. Schmitz: Death from pulmonary embolism associated with hydatidiform mole. Amer. J. Obstet. Gynec. 83, 1644 (1962).
Lloyd, C. E.: A case of hydatidiform mole associated with toxaemia. J. Obstet. Gynaec. Brit. Emp. 28, 307 (1921).
Logan, B. J., & L. Moytyloff: Hydatidiform mole. A clinical and pathological study of 72 cases with references to their malignant tendencies. Amer. J. Obstet. Gynec. 75, 1134 (1958).
Lumsden, J. W. F., & S. H. Tow: Two contrasting cases of chorioadenoma destruens. J. Obstet. Gynec. Brit. Cwlth. 68, 225 (1961).
Mac vicar, J.: Illustrative examples of ultrasonic echograms. Proc. Roy. Soc. Med. 55, 638 (1962).
I. Donald: Sonar in the diagnosis of early pregnancy and its complications. J. Obstet. Gynaec. Brit. Emp. 70, 387 (1963).
Madden, S.: Chorionepithelioma of the fallopian tube. J. Obstet. Gynaec. Brit. Emp. 57, 68 (1950).
Makino, S., M. S. Sasaki & T. Fukuschima: Preliminary notes on the chromosomes of human chorionic lesions. Proc. Jap. Acad. 39, 54 (1963).
— Triploid chromosome constitution in human chorionic lesions. Lancet ii, 1273 (1964).
Mall, F. P., & A. W. Meyer: Studies on abortuses. A survey of pathologic ova in the Carnegie embryological collection. Contrib. to Embryol., Wash., D. C. 12, No. 56 (1921).
Manahan, C. P., I. Benitez and F. Estrella: Amethopterin in the treatment of trophoblastic tumors. Amer. J. Obstet. Gynee. 82, 641 (1961).
Maqueo, M., J. Chavez azuela, S. Karchmer & J. Cmco arenas: Placental morphology in pathologic gestations with or without toxemia. Observations in cases of diabetes mellitus, hydrops fetalis, twin pregnancy, placenta previa, and hydatidiform mole. Obstet. Gynec. 26, 184 (1965).
Marchand, F.: Über die sogenannten „decidualen“Geschwülste im Anschluß an normale Geburt, Abort, Blasenmole und extrauterine Schwangerschaft. Monatsschr. Geburtsh. Gynäk. 1, 419, 513 (1895).
Marcuse, P. M.: Pulmonary syncytial giant cell embolism — Report of maternal death. Obstet. Gynec. 3, 210 (1954).
Mark, L. K., & M. Moel: Pulmonary metastasis from trophoblastic tumors. Radiology 76, 601 (1961).
Marquez-monter, H.: Deoxyribonucleic acid synthesis of hydatidiform moles in organ culture: an autoradiographic investigation. Nature 209, 1037 (1966).
Marquez-monter, H., G. A. de la Vega, M. Robles & A. Boliocicero: Epidemiology and pathology of hydatidiform mole in the General Hospital of Mexico. Study of 104 cases. Amer. J. Ôbstet. Gynec. 85, 856 (1963).
Mathieu, A.: Hydatidiform mole and chorioepithelioma. Internat Abst. Surg. 68, 52, 181 (1939).
Mckay, D. G., A. T. Hertig, E. C. Adams & M. V. Richardson: Histochemical observations on the human placenta. Obstet. Gynec. 12, 1 (1958).
M. V. Richardson & A. T. Hertig: Studies of the function of early human trophoblast. III. A study of the protein structure of mole fluid, chorionic and amniotic fluids by paper electrophoresis. Amer. J. Obstet. Gynec. 75, 699 (1958).
C. D. Roby, A. T. Hertig & M. V. Richardson: Studies of the function of early human trophoblast. I. Observations on the chemical composition of the fluid of hydatidiform mole. Amer. J. Obstet. Gynec. 69, 722 (1955).
— Studies of the function of early human trophoblast. II. Preliminary observations on certain chemical constituents of chorionic and early amniotic fluid. Amer. J. Obstet. Gynec. 69, 735 (1955).
Merchante, F. R.: Mola distopica terebrante. Obstet. Ginec. Latino-Am. 11, 451 (1953).
Meyer, A. W.: Hydatidiform degeneration in tubal pregnancy. Surg. Gynec. Obstet. 28, 293 (1919).
Meynard, M. M.: Perforations uterines douze jours après un avortement molaire. Bull. Féd. Soc. Gynéc. Obstet. 14, 474 (1962).
Midgley, A. R.: localization of chorionic gonadotropin in the placenta. Transcript of the second rochester trophoblast conference. Edited by Lund, C. J., & H. A. Thiede. Department of Obstetrics and Gynecology of the University of Rochester School of Medicine and Dentistry, Rochester, New York, 1963 p. 91.
Miller, J.: A case of malignant hydatidiform mole with pulmonary metastases. Edinburgh Med. J. Suppl. 217, 1923–1924.
— Ectopic hydatidiform mole. South African Med. J. 27, 246 (1953).
Morrison, D. L.: Recurrent hydatidiform mole. J. Obstet. Gynaec. Brit. Cwlth. 71, 640 (1964).
De Neef, J. C.: Clinical Endocrine Cytology. New York 1965, Hoeber Medical Division.
Niesert, W.: „Destruierende” Blasenmole mit spontaner Uterusperforation. Zbl. Gynäk. 82, 1178 (1960).
Nilsson, L.: Hydatidiform degeneration in aborted ova. A histopathological and clinical study. Acta Obstet. Gynec. Scand. 36, Suppl. 7: 1 (1957).
Novak, E.: Pathological aspects of hydatidiform mole and choriocarcinoma. Amer. J. Obstet. Gynec. 59, 1355 (1950).
C. S. Seah: Benign trophoblastic lesions in Mathieu Chorionepithelioma Registry (hydatidiform mole and syncytial endometritis). Amer. J. Obstet. Gynec. 68, 376 (1954).
Novak, E. R., & J. D. Woodruff: Novak’s Gynecologic and Obstetric Pathology, Fifth edition. Philadelphia, 1962, W. B. Saunders.
Noyés, R. W.: Trophoblast: problems of invasion and transport. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 54 (1959).
Ober, W. B.: Historical perspectives on trophoblast and its tumors. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 3 (1959).
Park, W. W.: The occurrence of sex chromatin in chorionepitheliomas and hydatidiform moles. J. Path. Bact. 74, 197 (1957).
— Experimental trophoblastic embolism of the lungs. J. Path. Bact. 75, 257 (1958).
— Aspects of choriocarcinoma in the female. In: Trophoblast and its tumors. Ann. N. Y. Acad. Sci. 80, 152 (1959).
— Disorders arising from the human trophoblast. In: Modern Trends in Pathology. Edited by Collins, D. H. New York, Paul. B. Hoeber (1959).
J. C. Lees: Choriocarcinoma: A general review, with analysis of five hundred and sixteen cases. Arch. Path. 49, 73, 205 (1950).
Payne, F. L.: Hormone studies in the presence of hydatidiform mole and ehorio- epithelioma. Surg. Gynec. & Obstet. 73, 86 (1941).
Pettit, M. de W.: Hydatidiform mole following tubal pregnancy. Amer. J. Obstet. Gynec. 42, 1057 (1941).
Price, W. E.: Invasive hydatidiform mole in the urinary bladder. Minn. Med. 43, 466 (1960).
Qjanen, R.: Hydatidiform degeneration in tubal pregnancy. Ann. Chir. Gynaec. Fenniae 479, 134 (1958).
Reed, S., J. I. Coe & J. Berquist: Invasive hydatidiform mole metastatic to the lungs. Obstet. Gynec. 13, 749 (1959).
Rigano, A., & R. Sermann: Prime osservazioni sull’ultrastruttura del villo coriale nella degenerazione vesicolo-molare. Riv. Ostet. Ginec. 18, 12 (1963).
Roca, J.: Uterine arteriography in hydatidiform mole. Amer. J. Roentgen. Radiol. Ther. Nuclear Med. 87, 287 (1962).
Ruyck, R. De: De la présence d’éléments corpusculaires particuliers et filtrables dans une môle hydatiforme compliquée de chorioépitheliome. Compt. Rend. Ac. Sc. 231, 1106 (1950).
Salvaggio, A. T., G. Nigogosyan & H. C. Mack: Detection of trophoblast in cord blood and fetal circulation. Amer. J. Obstet. Gynec. 80, 1013 (1960).
Sasaki, M., T. Fukuschima & S. Makino: Some aspects of the chromosomal constitution of hydatidiform moles and normal chorionic villi. Gann 53, 101 (1962).
Sauramo, H.: Cytotrophoblast of the placenta and fetal membranes in normal and pathological obstetrics. Ann. Med. Exp. Fenn. 39, 7 (1961).
Savage, M. B.: Trophoblast lesions of the lung following benign hydatidiform mole. Amer. J. Obstet. Gynec. 62, 346 (1951).
Schebat, L., J. J. Galley & E. Schebat: Un cas de grossesse gémellaire avec môle embryonée de l’un des oeufs. Bull. Féd. Soc. Gynec. Obst. Franc. 14, 530 (1962).
Schiffer, M. A., W. Pomerance & A. Mackles: Hydatidiform mole in relation to malignant disease of the trophoblast. Amer. J. Obstet. Gynec. 80, 516 (1960).
Schmorl, C. G.: Über das Schicksal embolisch verschleppter Plazentarzellen. Verhandl. deutsch, path. Ges. 8, 39 (1905).
Schulze, M.: Hydatidiform mole and chorionepithelioma. A clinical, pathological, and hormonal study. Clinics 1, 685 (1942).
Scott, J. S.: Pregnancy toxaemia associated with hydrops foetalis, hydatidiform mole and hydramnios. J. Obstet. Gynaec. Brit. Emp. 65, 689 (1958).
Sitaratna, A., & V. Sarma: Twin pregnancy: Well-formed hydatidiform mole associated with normal viable child. J. Obstet. Gynaec. Brit. Emp. 62, 301 (1960).
Smalbraak, J.: Trophoblastic Growths. 1957, Elsevier, Amsterdam.
—: Problems in the classification of hydatidiform moles. In: Trophoblast and its Tumors. Ann. N. Y. Acad. Sci. 80, 105 (1959).
Spademan, L. C., & W. M. Tuttle: Chorioadenoma destruens. Amer. J. Obstet. Gynec. 88, 549 (1964).
Stolte, L. A. M., H. I. A. M. V. Kessel, J. C. Seelen & G. A. J. Tijdink: Chromosomes in hydatidiform moles. Lancet ii, 1144 (1960).
Storch, E. D.: Fälle von sogenannten partiellem Myxom der Plazenta. Virch. Arch, path. Anat. 72, 582 (1878).
Stroup, P. E.: Study of 38 cases of hydatidiform mole at Pennsylvania Hospital. Amer. J. Obstet. Gynec. 72, 294 (1956).
Sutherland, C. G.: Tubal mole associated with intrauterine pregnancy. Amer. J. Obstet. Gynec. 65, 1146 (1954).
Szulman, A. E.: Chromosomal aberrations in spontaneous human abortions. New Engl. J. Med. 272, 811 (1965).
Tenney, B., & F. Pauker: Hydatidiform mole and chorionepithelioma. New Engl. J. Med. 221, 598 (1939).
Thiele, R. A., & R. R. De Alvarez: Metastasizing benign trophoblastic tumors. Amer. J. Obstet. Gynec. 84, 1395 (1962).
Thomas, L., G. W. Douglas & M. C. Carr: The continued migration of syncytial trophoblasts from the fetal placenta into the maternal circulation. Trans. Ass. Amer. Phys. 72, 140 (1959).
N. M. Gullen & M. G. Carr: Migration of fetal trophoblasts into maternal blood. Fed. Proc. 18, 601 (1959).
Tobin, S. M.: A further aid in the diagnosis of hydatidiform mole the serum glutamic oxalacetic transaminase. Amer. J. Obstet. Gynec. 87, 213 (1963).
Uher, J., J. E. Jirasek & A. Sima: Histochemische Studie von Blasenmole und Plazenta eines fünf Monate alten Fetus. Zbl. Gynäk. 85, 477 (1963).
Valente, P. A.: On a rare case of Breus’ mole in an ectopic site. Rass. Int. Clin. Ter. 39, 753 (1959).
Viet, J.: Über Deportation von Chorionzotten (Verschleppung von Zotten in mütterliche Blutbahnen). Z. Geburth. Gynäk. 44, 466 (1901).
Vojta, M., & J. Jirasek: Probleme der molaren Degeneration des Chorion. Zbl. Gynäk. 87, 1215 (1965).
Waltz, H. K., W. W. Tullner, V. J. Evans, R. Hertz & W. R. Earle: Chorionic gonadotropin recovery from hydatid mole grown in tissue culture. Abstr. Proc. Amer. Assoc. Cancer Res. 1, 57 (1953).
Wenner, P., A. Hauser & H. P. Klinger: Geschlechtsbestimmung mit Hilfe des Sex Chromatins bei Molen und Spontanaborten. Internat. Gynäk. Kongreß, Wien (1957).
Westerhout, F. C., Jr.: Ruptured tubal hydatidiform mole. Obstet. Gynec. 23, 138 (1964).
Wide, F., & B. Hobson: New method for diagnosis of hydatidiform mole. Lancet ii, 699 (1964).
Williams, T. J.: Hydatidiform mole and associated tumors of the chorion. Amer. J. Obstet. Gynec. 45, 433 (1943).
Wilson, R. B., J. S. Hunter & M. B. Dockerty: Chorioadenoma destruens. Amer. J. Obstet. Gynec. 81, 546 (1961).
Wislocki, G. B., & E. W. Dempsey: Histochemical age changes in normal and pathological placental villi (hydatidiform mole, eclampsia). Endocrinology 38, 90 (1946).
Wynn, R. M.: Fine structure of transplanted human choriocarcinoma and its endocrine function. Transcript of the Second Rochester Trophoblast Conference. P. 58. Edited by Lund, C. J., & H. A. Thiede. Department of Obstetrics and Gynecology of the University of Rochester School of Medicine and Dentistry, Rochester, New York, 1963.
Wynn, R. M.: Electron microscopy of neoplastic trophoblast. Obstet. Gynec. 23, 634 (1964).
Zenker, I. V.: Destruierende Blasenmole mit Spontanperforation des Uterus. Zbl. Gynäk. 84, 93 (1963).
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Benirschke, K., Driscoll, S.G. (1967). Tumors of the Placenta. In: The Pathology of the Human Placenta. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9809-0_14
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