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Abstract

With the exception of the rare tumors of the umbilical cord, only two tumorous processes occur in the placenta, one of which, the chorioangioma, may not represent a true neoplasm. In contrast, the chorionepithelioma or choriocarcinoma is a truly malignant neoplasm of the chorionic epithelium, the trophoblast. In most reports dealing with neoplasms of the placenta, particularly the larger reviews (Briquel; Meyer; Hertig & Mansell; Smalbraak), the hydatidiform mole is also included as a tumorous condition. We do not share this view, but regard the molar swelling of villi as a degenerative change and the occasional sequel, the development of a choriocarcinoma, as a basically unrelated outcome of this degeneration. To accentuate this distinction, we have chosen to separate these conditions in this review and hope that it will serve to promote investigation designed to elucidate the possible etiologic connections between the two processes.

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Benirschke, K., Driscoll, S.G. (1967). Tumors of the Placenta. In: The Pathology of the Human Placenta. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-9809-0_14

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