Abstract
In the last decade considerable evidence has established the importance of free radicals as mediators of the inflammatory response (1–4). Ever since free-radical reactions were first implicated in this process, their relevance to the development of associated pathological changes has been sought. McCord (5) was the first to suggest that such reactions may mediate the joint injury occurring in rheumatoid arthritis (RA); and this has led to the use of superoxide dismutase (SOD) and drugs with SOD-like activity in the treatment of RA and related disorders (6,7).
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References
B. M. Babior, R. S. Kipnes and J. T. Curnutte, J. Clin. Invest., 52, 741 (1973).
Y. Oyanagui, Biochem. Pharmacol., 25 1465 (1976).
Y. Oyanagui, Biochem. Pharmacol., 25, 1475 (1976).
M. L. Salin and J. M. McCord, J. Clin. Invest., 56, 1319 (1975).
J. M. McCord, Science, 185, 529 (1974).
K. Lund-Olesen and K. B. Menander, Curr. Therap. Res., 16, 706 (1974).
J. R. J. Sorenson, J. Med. Chem., 19 135 (1976).
J. Stocks, J. M. C. Gutteridge, R. J. Sharp and T. L. Dormandy, Clin. Scio Mol. Med., 47 223 (1974).
D. J. Al-Timini and T. L. Dormandy, Biochem. J., 168, 283 (1978).
A. Lorber, L. S. Cutler and C. C. Chang, Arthr. Rheum., 11, 65 (1968).
W. Niedermeier, Ann. Rheum. Dis., 24, 544 (1965).
K. S. Chio and A. L. Tappel, Biochemistry, 8, 2827, (1969).
J. Lunec and T. L. Dormandy, Clin. Sci., 56, 53 (1979).
J. Lunec and T. L. Dormandy, J. Rheumatol, 8, 233, (1981).
D. Wickens, M. H. Wilkins, J. Lunec, G. Ball and T. L. Dormandy, Ann. Clin. Biochem., 18, 158 (1981).
J. R. Lowe, M. E. Pickup, J. S. Dixon, P. A. Leatham, V. M. Rhind, V. Wright and W. W. Downie, Ann. Rheum. Dis., 37, 428 (1978).
A. Lorber, C. M. Pearson, W. L. Meredith and L. E. Gantz-Mandell, Ann. Intern. Med., 61, 423 (1964).
D. Gerber and K. Shum, Arthr. Rheum., 20, 116 (1977)
K. Hannestad, Clin. Exp. Immunol,, 2, 511 (1967).
P. M. Carter, Ann. Rheum. Dis., 2, 265 (1973).
D. Gerber, J. Immunol., 32, 885 (1964).
P. M. Johnson, J. Watkins, P. M. Scopes and B. M. Tracey, Ann. Rheum. Dis., 22, 366 (1974).
J. M. C. Gutteridge, J. Lunec and A. D. Heys, Anal. Lett., 7, 537 (1978).
N. R. Di Luzio, J. Agr. Pd. Chem., 20, 486 (1972).
A. L. Tappel in “Pathological Aspects of Cell Membranes” B. P. Trump and A. Arstilla, Eds., Academic Press, New York (1969), p 145.
I. D. Desai and A. L. Tappel, J. Lipid Res., 4 204 (1963).
J. M. C. Gutteridge, Ann. Clin. Biochem., 15 293 (1978).
I. M. Goldstein, H. B. Kaplan, H. E. S. Eddson and G. Weissmann, J. Biol. Chem., 254, 4040 (1979)•
J.D. Gitlin, J. I. Gltlin and D. Gitlin, Arthr. Rheum., 20, 1491 (1977).
A. Mullen and C. ¥. M. Wilson, Proc. Nutr. Soc., 35 8A (1976).
S. N. Pennington and C. P. Smith, Lipids, 13 636 (1978).
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Lunec, J., Wickens, D.G., Graff, T.L., Dormandy, T.L. (1982). Copper, Free Radicals and Rheumatoid Arthritis. In: Sorenson, J.R.J. (eds) Inflammatory Diseases and Copper. Experimental Biology and Medicine, vol 2. Humana Press. https://doi.org/10.1007/978-1-4612-5829-2_23
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DOI: https://doi.org/10.1007/978-1-4612-5829-2_23
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