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The Inflammatory Response to Acute Viral Infections

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Concepts in Viral Pathogenesis

Abstract

The inflammatory response to viral infections is characteristically composed of mononuclear cells. The full development of this response is an immunologically specific event that is dependent on the presence of sensitized T lymphocytes [1–4]. These mononuclear inflammatory cells represent a variety of functional cell types indistinguishable, for the most part, on the basis of conventional morphology. Critical studies of the inflammatory response have, to date, been limited almost exclusively to examination of mice with infections of the central nervous system, lung, or liver with enveloped viruses. Under these circumstances, inflammatory infiltrates at various stages of development are known to consist of T lymphocytes of the helper/delayed-type hypersensitivity (Lyt-1) and cytotoxic/suppressor (Lyt-2) phenotypes, B lymphocytes at various stages of differentiation, natural killer (NK) cells, and monocyte/macrophages. Infections of other organs and/or of other species with different, particularly nonenveloped, viruses may generate inflammatory patterns different from those reviewed here.

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Author information

Authors and Affiliations

  1. The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Diane E. Griffin

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  1. Diane E. Griffin
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Editors and Affiliations

  1. National Institutes of Health, 20205, Bethesda, Maryland, USA

    Abner Louis Notkins M.D.

  2. Department of Immunopathology, Scripps Clinic and Research Foundation, 92037, La Jolla, California, USA

    Michael B. A. Oldstone M.D.

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© 1984 Springer-Verlag New York Inc.

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Griffin, D.E. (1984). The Inflammatory Response to Acute Viral Infections. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5250-4_7

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  • DOI: https://doi.org/10.1007/978-1-4612-5250-4_7

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9756-7

  • Online ISBN: 978-1-4612-5250-4

  • eBook Packages: Springer Book Archive

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