Abstract
Viruses often have complicated life cycles in their natural hosts, replicating in a series of specific tissue types in a defined order that may even vary depending upon the route of inoculation. These viruses show distinct preferences for efficient replication in selected differentiated cell types and this has been termed tissue tropism. In order to understand viral pathogenesis at the molecular, cellular, or organismic levels, one must consider the differential regulation of viral genetic information in the great diversity of host-cell backgrounds that compose the organism. Not only can the stage of differentiation of a host cell affect viral gene expression [1], some viruses are capable of reprogramming or altering cellular gene expression, or the regulation of cell division, and in doing so produce a disease state [2]. The subject of this brief communication is to review the mechanisms that underlie virus-specific tissue tropisms and latency and to consider how these can result in defined pathology.
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© 1984 Springer-Verlag New York Inc.
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Levine, A.J. (1984). Viruses and Differentiation: The Molecular Basis of Viral Tissue Tropisms. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5250-4_19
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DOI: https://doi.org/10.1007/978-1-4612-5250-4_19
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