Summary
Neurochemical investigations demonstrate that normal brain aging is characterized by a moderate decrease in glycolytic turnover capacity. There is an age-dependent increase in soluble hexokinase activity and a significant decrease in activity of the key glycolytic enzyme phosphofructokinase. This decrease in the glycolytic turnover capacity lowers acetyl coenzyme A, necessary for the biosynthesis of acetylcholine. Therefore normal aging of the brain is additionally characterized by a moderate decline of the cholinergic activity. The monaminergic neurotransmitters also decrease, which results in a neurotransmitter imbalance.
In normal aging the brain stays within the limits of the functional reserve capacity. This reserve capacity can be exhausted by ischemic, traumatic, or toxic brain lesions, shifting the normal aging brain into a psychoorganic defect syndrome or a senile dementia.
In Alzheimer’s disease and in senile dementia of Alzheimer’s type, in addition to a decrease of mitochondrial hexokinase and phosphofructokinase activity, there is a significant decrease in aldolase, triosephosphate isomerase, phosphoglucose isomerase, and phosphogylceromutase activity. The functional consequence of this decrease in glycolytic energy supply is a massive impairment of acetylcholine synthesis, which is accompanied by a massive decline in choline acetyltransferase. Senile dementia can be defined as a cholinergic insufficiency of the brain. A drug treatment which improves the glycolytic turnover may be an etiological theraphy concept enhancing cholinergic brain activity by increasing acetyl coenzyme A and choline acetyltransferase activity.
Keywords
- Ergot Alkaloid
- Choline Acetyltransferase
- Senile Dementia
- Carbonic Anhydrase Activity
- Triosephosphate Isomerase
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Meier-Ruge, W. (1985). Neurochemistry of the Aging Brain and Senile Dementia. In: Gaitz, C.M., Samorajski, T. (eds) Aging 2000: Our Health Care Destiny. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5058-6_8
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DOI: https://doi.org/10.1007/978-1-4612-5058-6_8
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