Abstract
On the basis of data obtained in smooth muscles [1] it was assumed that substance P (SP) analogues containing D-amino acids will antagonise the spinal actions of tachykinins. It was however rapidly realised that SP antagonists exert direct effects on the rat spinal cord. In fact, undeca or C-terminal octapeptide analogues of SP containing D-Trp in positions 7 and 9 or 7,9 and 10 cause an initial increase of the blood pressure followed by a long lasting fall to levels below 80 mmHg within 20–30 min when applied intrathecally (i.th.). In a number of experiments, the hypotension was large enough to cause death of the animal [2, 3, 4].
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References
Regoli D, Escher E, Drapeau G, D’Orléans- Juste P, Mizrahi J (1984) Receptors for substance P. III. Classification by competitive antagonists. Eur J Pharmacol 97: 179–189.
Loewy AD, Sawyer WB (1982) Substance P antagonist inhibits vasomotor responses elicited from ventral medulla in rat. Brain Research 245: 379–383.
Yashpal K, Gauthier SG, Henry JL (1985) Substance P given intratheca11y at the spinal T9 level increases adrenal output of adrenaline and noradrenaline in the rat. Neuroscience 15 (2): 529–536.
Takano Y, Sawyer WB, Loewy AD (1985) Substance P mechanisms of the spinal cord related to vasomotor tone in the spontaneously hypertensive rat. Brain Res 334: 105–116.
Regoli D, Escher E, Mizrahi J (1984) Substance P: structure-activity studies and the development of antagonists. Pharmacology 28: 301–320.
Escher E, d’Orléans-Juste P, Dion S, Drapeau G, Mizrahi J, Regoli D (1984) A substance P antagonist not containing D-Tryptophane. Eur J Pharmacol 105; 375–377.
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© 1987 Springer-Verlag New York Inc.
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Couture, R., Gupta, A., Kérouac, R., Escher, E., Regoli, D. (1987). Characterization of Spinal Actions of Ten Substance P Analogs. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_57
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DOI: https://doi.org/10.1007/978-1-4612-4672-5_57
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