Abstract
The trace amines are a group of endogenous aromatic amines found in low concentrations in the nervous systems of many invertebrate and vertebrate species. They are a diverse group of compounds and it seems likely that they have diverse functions. It has been postulated that trace amines may act as neuromodulators (Boulton, 1976, 1980), false transmitters (Baldessarini, 1974), co-transmitters (Axelrod and Saavedra, 1977), or that they may be neurotransmitters in their own right (Jones, 1982b, Stoof et al. 1976).
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References
Axelrod, J. and Saavedra, J.M., (1977) Octopamine, Nature. 265, 501–504.
Baldessarini, J., (1974) Release of catecholamines. In Handbook of Psychopharmacology. Vol. 3 (I.I.I. Verson, S.D. Iverson and S.H. Snyder, Eds), p37–114, Plenum, New York and London.
Benkirane, S., Arbilla, S. and Langer, S.Z., (1986) Newly synthesised noradrenaline mediates the α2-adrenoreceptor inhibition of [3H]-5-hydroxytryptamine release induced by β-phenylethylamine inrat hippocampal slices, Eur. J. Pharmacol., 131, 189–198.
Boulton, A.A., (1976) Cerebral aryl alkyl aminergic mechanisms. In Trace Amines and the Brain (E. Usdin and M. Sandler, Eds), p22–39, Marcel Dekker, New York.
Boulton, A.A., (1980) The trace amines: Neurohumours, Behav. Brain Sci., 7, 418.
Boulton, A.A. and Baker, G.B., (1975) The subcellular distribution of β-phenylethylamine, p-tyramine and tryptamine in the rat brain, J. Neurochem., 25, 477–481.
Bradshaw, C.M., Roberts, M.H.T. and Szabedi, E., (1974) Effects of imipramine and desimipramine on responses of single cortical neurones to noradrenaline and 5-hydroxytryptamine, Br. J. Pharmacol., 52, 349–358.
Durden, D.A. and Phillips, S.R., (1980) Kinetic measurements of the turnover rates of phenylethylamine and tryptamine in vivo in the rat brain, J. Neurochem., 34, 1725–1732.
Durden, D.A., Phillips, S.R. and Boulton, A.A., (1973) Identification and distribution of β-phenylethylamine in the rat, Can. J. Biochem., 51, 995–1002.
Fuxe, K., Grobecker, H. and Jonsson, J., (1967) The effects of β-phenylethylamine on central and peripheral monoamine containing neurones, Eur. J. Pharmacol., 2, 202–207.
Hauger, R.L., Skolnick, P. and Paul, S.M., (1982) Specific [3H]-β-phenylethylamine binding sites in the rat brain, Eur. J. Pharmacol., 83, 147–148.
Horn, A.D. and Snyder, S.H., (1973) Steric requirements for catecholamine uptake by rat brain synaptosomes: studies with rigid analogues of amphetamine, J. Pharmacol, Exp. Ther., 180, 523–530.
Jones, R.S.G., (1981) Specific enhancement of neuronal responses to catecholamine by p-tyramine, J. Neurosci. Res. , 6, 49–61.
Jones, R.S.G., (1982a) Noradrenaline-octopamine interactions on cortical neurones in the rat, Eur. J. Pharmacol. , 77, 159–162.
Jones, R.S.G., (1982b) Tryptamine: a neuromodulator or neurotransmitter in mammalian brain?, Prog. Neurobiol., 19, 117–139.
Jones, R.S.G. and Boulton, A.A., (1980) Interactions between p-tyramine, m-tyramine or β-phenylethylamine and dopamine on single neurones in the cortex and caudate nucleus of the rat, Can. J. Physiol. Pharmacol., 58, 222–227.
Lundberg, P-.A., Oreland, L and Engberg, G., (1985) Inhibition of Locus Coeruleus neuronal activity by β-pheylethylamine, Life Sci. , 36, 1889–1896.
Niddam, R., Arbilla, S., Baud, P. and Langer, S.Z., (1985) [3H]-β-phenylethylamine but not [3H]-(±)-amphetamine is released by electrical stimulation from perfused rat striatal slices, Eur. J. Pharmacol., 110, 121–124.
Phillips, S.R., Rozdilsky, B. and Boulton, A.A., (1978) Evidence for the presence of m-tyramine, p-tyramine, tryptamine and phenyethylamine in the rat brain and several areas of the human brain, Biol. Psychiat., 13, 51–57.
Raiteri, M., Del Carmine, R., Bertollini, A. and Levi, G., (1977) Effect of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine and 5-hydroxytryptamine, Eur. J. Pharmacol., 41, 133–143.
Stoof, J.C., Liem, A.L. and Mulder, A.H., (1976) Release and receptor stimulating properties of p-tyramine in rat brain, Arch. Int. Pharmacodynam., 220, 62–71.
Ungerstedt, U., (1971) Stereotaxic mapping of the monoamine pathways in the rat brain, Acta Physiol. Scand. Suppl., 367, 1–48.
Wu, P.H. and Boulton, A.A., (1975) Metabolism, distribution and disappearance of injected β-phenylethylamine in the rat, Can. J. Biochem., 53, 42–50.
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Paterson, I.A. (1988). An Interaction between β-Phenylethylamine and Noradrenaline: An Iontophoretic Study in the Rat Cerebral Cortex. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_17
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_17
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