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Drug Delivery Related to Tissue Engineering

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Synthetic Biodegradable Polymer Scaffolds

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Abstract

Success of tissue engineering depends on many factors. Host response to the scaffold, template, or the cell-seeded implant is one of the critical parameters. The concept of using pharmacological means to redirect or effect a favorable biological response during the course of tissue reconstruction is appealing. Examples abound on the incorporation of a drug delivery function into prostheses (Greco, 1994). For instance, antimicrobial agents have been embedded in bone cement or catheters to combat infection, and antithrombogenic agents have been incorporated into or conjugated to the surface of vascular grafts to minimize thrombosis. Recent discoveries of potent polypeptides that can influence the course of cell maturation and development accentuate the importance of considering delivery of these factors in designing a scaffold for tissue regeneration. A prime example is bone regeneration.

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  1. Department of Biomedical Engineering, The Johns Hopkins University, School of Medicine, 21205, Baltimore, MA, USA

    Kam W. Leong PhD

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  1. Kam W. Leong PhD
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Editors and Affiliations

  1. Laboratory for Tissue Engineering, Division of Urology and Department of Surgery, Children’s Hospital and Harvard Medical School, 300 Longwood Avenue, 02115, Boston, MA, USA

    Anthony Atala MD (Director) (Director)

  2. Departments of Biologic and Materials Sciences and Chemical Engineering, The University of Michigan, 48109, Ann Arbor, MI, USA

    David J. Mooney PhD

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© 1997 Birkhäuser Boston

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Leong, K.W. (1997). Drug Delivery Related to Tissue Engineering. In: Atala, A., Mooney, D.J. (eds) Synthetic Biodegradable Polymer Scaffolds. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4154-6_6

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  • DOI: https://doi.org/10.1007/978-1-4612-4154-6_6

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-8677-6

  • Online ISBN: 978-1-4612-4154-6

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