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Glucose and lipid metabolism in the gold thioglucose injected mouse model of diabesity

  • Chapter
Lessons from Animal Diabetes VI

Part of the book series: Rev.Ser.Advs.Research Diab.Animals (Birkhäuser) ((RSARDA,volume 6))

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Abstract

Gold thioglucose (GTG) (C6H11O5SAu) was initially developed and marketed as a therapeutic agent for the treatment of arthritis and rheumatism (Fig. 1). During toxicology studies, it was noted by Brecher and Waxier1 that a single i.p. or s.c. injection of GTG induced a syndrome of hyperphagia and obesity in mice. This observation was subsequently confirmed by Marshall and colleagues,2 who reported that GTG induced bilateral necrosis of the ventromedial hypothalamus (VMH) region of the brain and caused damage to the supraoptic nuclei, ventromedial nuclei, arcuate nuclei, and median eminence. These GTG-induced lesions in the hypothalamus of mice did not appear to impair central functions other than the regulation of food intake and body wt.3 The degree of obesity induced by GTG in mice is dependent on the dose of GTG administered and the particular strain of mice used.2,4 In general, the larger the dose of GTG administered, the greater the gain in body wt.5 Administration of a range of doses of GTG has been shown to induce variable wt gain and mortality in the C58, RIII, DBA, and BALB/C strains of mice compared with the CBA strain. CBA mice appear to be unique in that they exhibit a uniform response with respect to these two parameters.6

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Authors and Affiliations

  1. Department of Endocrinology, Royal Prince Alfred Hospital, 2050, Camperdown, NSW, Australia

    Dr. Stephen C. Blair, Dr. Stephen C. Blair, Ian D. Caterson & Gregory J. Cooney

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  2. Ian D. Caterson
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  3. Gregory J. Cooney
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  1. Department of Biochemistry, Hadassah Medical Center, POB 12000, IL 91120, Jerusalem, Israel

    Eleazar Shafrir

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© 1996 Birkhäuser Boston

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Blair, S.C., Caterson, I.D., Cooney, G.J. (1996). Glucose and lipid metabolism in the gold thioglucose injected mouse model of diabesity. In: Shafrir, E. (eds) Lessons from Animal Diabetes VI. Rev.Ser.Advs.Research Diab.Animals (Birkhäuser), vol 6. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4112-6_15

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  • DOI: https://doi.org/10.1007/978-1-4612-4112-6_15

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