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Renal Actions of Atrial Natriuretic Peptide

  • Chapter
Natriuretic Peptides in Health and Disease

Part of the book series: Contemporary Endocrinology ((COE,volume 5))

Abstract

As of 1956, Henry and Gauer (1) stated that the heart is involved in renal functions. This was supported in 1969 by Lockett and coworkers, who mentioned for the first time a hormonal influence of the heart on the kidney (2). In 1976, Marie and coworkers (3) observed that the granular index of myoendocrine cells is affected during experiments, altering the body fluid and electrolyte homeostasis. By applying atrial extracts, deBold and Sonnenberg (4) reported for the first time an up to then unknown strong diuresis and natriuresis. Then, a further biological effect of atrial extracts, relaxation of vascular smooth muscle, was discovered (5–8). Based on these two main biological effects, the first isolation of atrial natriuretic peptides was performed. Depending on the bioassay used for isolation, the peptides were designated cardiodilatin (from the pig) (8), cardionatrin (from the rat) (9). Kangawa and coworkers (10) were the first to isolate the hormone from the human heart. They designated the peptide human a atrial natriuretic peptide (h α ANP), which will also be used in the following text. Since then, remarkable advances have been made regarding the characterization of its gene and protein nature, synthesis, intracellular processing, release, metabolism, second messenger systems, and receptors (11–14). The main function of ANP is perceived to be an action on the kidney to induce natriuresis and diuresis (15–17).

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Authors
  1. Markus Meyer
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  2. Wolf-Georg Forssmann
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Editors and Affiliations

  1. Department of Physiology, University of North Dakota School of Medicine, Grand Forks, ND, USA

    Willis K. Samson PhD

  2. Department of Medicine and Pharmacology, University of California at Irvine, USA

    Ellis R. Levin MD

  3. Department of Veterans Affairs Medical Center, Long Beach, CA, USA

    Ellis R. Levin MD

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Meyer, M., Forssmann, WG. (1997). Renal Actions of Atrial Natriuretic Peptide. In: Samson, W.K., Levin, E.R. (eds) Natriuretic Peptides in Health and Disease. Contemporary Endocrinology, vol 5. Humana Press. https://doi.org/10.1007/978-1-4612-3960-4_9

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  • DOI: https://doi.org/10.1007/978-1-4612-3960-4_9

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