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Papovaviridae: The Papillomaviruses

  • Chapter
Laboratory Diagnosis of Infectious Diseases Principles and Practice

Abstract

Disease: Skin warts, anogenital warts (condyloma acuminatum, cervical intraepithelial neoplasia, bowenoid papulosis), oral and laryngeal papillomas, conjunctival papillo-mas, focal epithelial hyperplasia Heck; anogenital cancer, laryngeal carcinomas, tongue carcinomas, skin carcinomas of patients with epidermodysplasia verruci-formis.

Etiologic Agents: Human papillomavirus genotypes 1 to 46.

Source: Man by direct contact.

Clinical Manifestations: Circumscribed benign tumors of skin and mucosa, which frequently regress spontaneously. Specific lesions may progress to cancer. Subclinical infections frequent.

Pathology: Epithelial tumors, showing acanthosis and variable degrees of papillomatosis and hyperkeratosis.

Laboratory Diagnosis: Demonstration of virus particles in the electron microscope and, more convenient, of virus capsid antigen by means of a genus-specific antiserum in a PAP test. Identification and typing of viral DNA by nucleic acid hybridization.

Epidemiology: Worldwide incidence at least 20% of the population. Some human papillomavirus types restricted to ethnic groups.

Treatment: Surgical therapy (excision, curettage, laser), application of caustic agents, cryotherapy, interferon.

Prevention and Control: Disinfection, prevention of sexual transmission. No vaccine available yet.

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Pfister, H. (1988). Papovaviridae: The Papillomaviruses. In: Laboratory Diagnosis of Infectious Diseases Principles and Practice. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3900-0_16

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  • DOI: https://doi.org/10.1007/978-1-4612-3900-0_16

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