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Peripheral Blood Cell Biological Markers in Depression

  • Chapter
New Directions in Affective Disorders

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Abstract

The classical monoamine hypotheses of depressive illness have postulated a deficiency of norepinephrine and/or serotonin at functionally important receptors in the central nervous system (CNS).1,2 An alternative “receptor hypothesis” would explain reduced transmission by a deficiency in signal amplification by the receptor complex. This focus on the receptor gained impetus from studies showing that virtually all effective somatic antidepressant treatment modalities shared the common effect of down-regulation and/or desensitization of β-adrenergic receptor complexes.3,4 Moreover, a significant number of antidepressants down-regulate 5- HT2 (serotonin; 5-hydroxytryptamine) receptors, although, in contrast, electroconvulsive shock up-regulates 5-HT2 receptors.4,5

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Authors
  1. J. John Mann
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  2. James P. Halper
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  3. Richard P. Brown
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  4. P. Anne McBride
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  5. John A. Sweeney
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  6. Ann Peters
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  7. Philip J. Wilner
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Editor information

Editors and Affiliations

  1. Jerusalem Mental Health Center-Ezrath Nashim, 91001, Jerusalem, Israel

    Bernard Lerer M.D. (Director of Research, Associate Professor) (Director of Research, Associate Professor)

  2. Department of Psychiatry, Hebrew University, 91001, Jerusalem, Israel

    Bernard Lerer M.D. (Director of Research, Associate Professor) (Director of Research, Associate Professor)

  3. University of Pittsburgh, 15213, Pittsburgh, PA, USA

    Samuel Gershon M.D. (Vice President for Research in the Medical and Health Care Division; Associate Vice President for Research in the Health Sciences, Professor of Psychiatry, Associate Research Director for Neurosciences) (Vice President for Research in the Medical and Health Care Division; Associate Vice President for Research in the Health Sciences, Professor of Psychiatry, Associate Research Director for Neurosciences)

  4. Department of Psychiatry, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA

    Samuel Gershon M.D. (Vice President for Research in the Medical and Health Care Division; Associate Vice President for Research in the Health Sciences, Professor of Psychiatry, Associate Research Director for Neurosciences) (Vice President for Research in the Medical and Health Care Division; Associate Vice President for Research in the Health Sciences, Professor of Psychiatry, Associate Research Director for Neurosciences)

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© 1989 Springer-Verlag New York Inc.

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Mann, J.J. et al. (1989). Peripheral Blood Cell Biological Markers in Depression. In: Lerer, B., Gershon, S. (eds) New Directions in Affective Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3524-8_45

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  • DOI: https://doi.org/10.1007/978-1-4612-3524-8_45

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-96769-1

  • Online ISBN: 978-1-4612-3524-8

  • eBook Packages: Springer Book Archive

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