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Granulocyte Colony-Stimulating Factor

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Peptide Growth Factors and Their Receptors I

Part of the book series: Springer Study Edition ((SSE))

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Abstract

Granulocyte colony-stimulating factor (G-CSF) is one of the colony-stimulating factors (CSF) which stimulate colony formation from bone marrow cells. Of the four well-known CSFs, G-CSF is the one that specifically regulates proliferation, differentiation, survival, and activation of cells of the restricted neutrophilic granulocyte lineage (Metcalf 1985, 1986, 1987; Sachs 1987). Mouse G-CSF is also called MGI-1G (macrophage and granulocyte inducer type1, granulocyte) while human G-CSF has been designated pluripotent CSF (pluripoetin) or granulocyte-macrophage colony-stimulating factor ß (GM-CSFß). Recombinant DNA technology has been used to elucidate the molecular and genetic nature of G-CSF (Clark and Kamen 1987) and in vitro and in vivo functions of G-CSF have been extensively studied using recombinant G-CSF. Recent clinical application of G-CSF has shown that this hormone is valuable in the treatment of patients suffering from neutropenia. In this article, current information on G-CSF gene structure and function will be reviewed.

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  1. S. Nagata
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  1. Laboratory of Chemoprevention, National Cancer Institute, 20892, Bethesda, MD, USA

    Michael B. Sporn M.D.  & Anita B. Roberts Ph.D.  & 

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Nagata, S. (1991). Granulocyte Colony-Stimulating Factor. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Springer Study Edition. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3210-0_16

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  • DOI: https://doi.org/10.1007/978-1-4612-3210-0_16

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