Abstract
Recent reports in the literature (Lingham et al, 1990; Spinosa et al, 1988) have shown that angiotensin converting enzyme (ACE) inhibitors decrease ethanol consumption in rats. A clinical trial by Naranjo and his colleagues (see these proceedings) was conducted to determine whether enalapril was effective in decreasing ethanol consumption in normotensive moderately dependent drinkers. We concurrently tested three ACE inhibitors, enalapril, benazepril and abutapril in rats using a 24 hour unlimited access free choice drinking model.
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References
Lingham, T., Perlanski, E. and Grupp, LA. Angiotensin converting enzyme inhibitors reduce alcohol consumption: Some possible mechanisms and important conditions for its therapeutic use. Alcoholism: Clin. Exp. Res. 14 (1): 92–99 (1990).
Spinosa, G., Perlanski, E., Leenan, F.H.H., Stewart, R.B. and Grupp, LA. Angiotensin converting enzyme inhibitors: Animal experiments suggest a new pharmacological treatment for alcohol use in humans. Alcoholism: Clin. Exp. Res. 12(1): 65–70 (1988).
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© 1992 Springer-Verlag New York, Inc.
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Brands, B., Naranjo, C.A., Tighe, J.W., Collis, R.S., Sellers, E.M. (1992). Effects of Angiotensin Converting Enzyme Inhibitors on Free Choice Ethanol Consumption by Rats. In: Naranjo, C.A., Sellers, E.M. (eds) Novel Pharmacological Interventions for Alcoholism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2878-3_45
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DOI: https://doi.org/10.1007/978-1-4612-2878-3_45
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