Abstract
Drug-induced changes in the voluntary intake of ethanol by experimental animals are known to be influenced by the appetite for calories and for water. Thus, at least a part of these changes can be considered nonspecific for ethanol. It is convenient to know which part of the effect is not due to the caloric value or the water of ethanol solution, since it can be considered as a specific change. We have proposed a method for recognizing such specific effect by simultaneously measuring the changes in the consumption of ethanol solution, water and solid food, and by analyzing data in a particular way, the rationale of which was also discused (ALCOHOL 5: 15–19, 1988). We have applied this method to the effects of some drugs acting on CNS in rats genetically low (UChA) and high (UChB) ethanol consumer. The results show that Disulfiram, Cyanamide, Pyrazole, Clofibrate, 5-HTP, PCPA, Sulpiride, Sch 23390, Metamphetamine, MDMA, Clonidine, AMPT, Benserazide Carbidopa, Diazepam, Caffeine, Aminophylline and Oxyphenonium decrease specifically ethanol intake in UChB rats; while Haloperidol, Chlorpromazine, Sulpiride, Diazepam, Atropine and Trihexyphenidyl, increase it in UChA rats. Other drugs did not show specific effect in rats of any of the strains. These results are useful for recognizing the kind of neurons playing a role in the mechanisms of appetite for and satiety with ethanol, and also as an aid in the choice of drugs to be tested in the treatment of alcoholism.
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Mardones, J., Alvarado, R., Contreras, S., Segovia-Riquelme, N. (1992). Drug-Induced Specific and Nonspecific Changes in Voluntary Ethanol Intake by Rats. In: Naranjo, C.A., Sellers, E.M. (eds) Novel Pharmacological Interventions for Alcoholism. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2878-3_20
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DOI: https://doi.org/10.1007/978-1-4612-2878-3_20
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